两种助孕方式下D5、D6囊胚行冻融移植后妊娠结局的比较

发布时间：2018-08-24 11:36

【摘要】：目的比较体外受精-胚胎移植(ⅣF-ET)与胚胎植入前遗传学诊断或胚胎植入前遗传学筛查(PGD/PGS)周期中D5、D6囊胚形成情况及妊娠结局,同时探究D5、D6囊胚的发育潜能及两种助孕方式的优劣。方法回顾性分析行ⅣF-ET助孕的138个周期及PGD/PGS筛查助孕的148个周期,按移植胚胎的发育天数分为ⅣF-D5组、ⅣF-D6组、PGD/PGS-D5组和PGD/PGS-D6组,分析比较各组的一般情况、囊胚形成情况及冻融移植后的种植率、临床妊娠率、流产率等。结果ⅣF-D5组与ⅣF-D6组相比、PGD/PGS-D5组与PGD/PGS-D6组相比,D5组囊胚形成率、优质胚胎率、种植率、临床妊娠率均高于D6组(P0.05);PGD/PGS周期中D5组整倍体囊胚检出率高于D6组(P0.05);ⅣF-D5组与PGD/PGS-D5组相比、ⅣF-D6组与PGD/PGS-D6组相比,两组间的囊胚形成率、优质胚胎率、种植率及临床妊娠率均差异无统计学意义。结论两种助孕方式下冻融移植D5囊胚比D6囊胚可获得较好的临床妊娠结局;与ⅣF相比,PGD/PGS并未明显改善患者的妊娠结局。
[Abstract]:Objective to compare the blastocyst formation and pregnancy outcome between in vitro fertilization-embryo transfer (F-ET) and pre-implantation genetic diagnosis or pre-implantation genetic screening (PGD/PGS) cycle. At the same time, the developmental potential of D _ 5 D _ 6 blastocyst and the advantages and disadvantages of two ways of assisting pregnancy were investigated. Methods 138 cycles of 鈪，

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