VEGF和孕酮联合检测在早期妊娠诊断中的临床价值

发布时间：2018-08-25 10:58

【摘要】：目的研究讨论VEGF和孕酮联合检测对于早期妊娠患者诊断的临床价值。方法选取2014年6月~2016年5月在我院妇产科就诊的256例宫外孕患者(研究组)及同期在260例正常妊娠妇女(对照组)检测值进行对比分析。结果对照组孕酮值显著高于研究组,差异有统计学意义(P0.05);对照组的VEGF值则低于研究组,差异有统计学意义(P0.05)。孕酮的参考值为15.8 nmol/L,ROC曲线下面积为0.82;VEGF的参考值为238.6 pg/m L,ROC曲线下面积为0.87;孕酮+VEGF的曲线下面积为0.96。研究组与对照组患者联合使用VEGF和孕酮检测的特异度、敏感度及准确度都比单独使用VEGF或孕酮高,差异有统计学意义(P0.05)。结论联合使用VEGF和孕酮检测早期异位妊娠的特异度、敏感度及准确度都比单独使用VEGF或孕酮高,因此,在临床上,可以推广此二种检测联合的方式,以期增加早期异位妊娠患者的检出率,使患者能够及时住院治疗及终止妊娠,降低异位妊娠患者的死亡率,提高治愈率。
[Abstract]:Objective to study the clinical value of combined detection of VEGF and progesterone in early pregnancy. Methods from June 2014 to May 2016, 256 ectopic pregnancy patients (study group) and 260 normal pregnant women (control group) in our hospital from June 2014 to May 2016 were compared and analyzed. Results the value of progesterone in the control group was significantly higher than that in the study group, the difference was statistically significant (P0.05), while the VEGF value in the control group was lower than that in the study group (P0.05). The reference value of progesterone is 15. 8 nmol/L,ROC curve. The area under 0. 82 nmol/L,ROC curve is 0. 87 for progesterone VEGF curve and 0. 96 for progesterone VEGF curve. The specificity, sensitivity and accuracy of combined use of VEGF and progesterone in study group and control group were higher than those in VEGF or progesterone alone (P0.05). Conclusion the specificity, sensitivity and accuracy of combined use of VEGF and progesterone in the detection of early ectopic pregnancy are higher than those in VEGF or progesterone alone. In order to increase the detection rate of early ectopic pregnancy, the patients can be hospitalized and terminated in time, the mortality rate of ectopic pregnancy can be reduced, and the cure rate can be improved.
【作者单位】：深圳市保安区福永镇福永人民医院妇产科;
【分类号】：R714.15

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