子宫肌瘤组织硫酸基转移酶1A3与雌激素受体亚型ERα、ERβ的表达及临床意义研究

发布时间：2018-08-28 12:51

【摘要】：目的探讨硫酸基转移酶基因1A3(SULT1A3)、雌激素受体亚型(ERα、ERβ)在子宫肌瘤组织中的表达及其与子宫肌瘤发病的相关性。方法选取2013年10月至2015年6月中国医科大学附属盛京医院妇科收治的30例因子宫肌瘤(单发型)住院行全子宫切除术或子宫肌瘤剔除术患者和10例因子宫脱垂且无其他子宫病变,行全子宫切除术患者的石蜡组织标本。免疫组化法检测SULT1A3与ERα、ERβ在30例子宫肌瘤组织以及相应肌瘤包膜外组织与10例正常子宫肌层组织中的表达及其差异性。结果与肌瘤包膜外肌层组织及正常子宫肌层组织相比较,子宫肌瘤组织中SULT1A3的表达显著降低(P0.05),而雌激素受体ERα、ERβ的表达明显增高(P0.05)。在子宫肌瘤组织中,SULT1A3与ERβ之间存在显著的负相关性(P0.05),与ERα之间无相关性(P0.05)。结论 SULT1A3在子宫肌瘤发生发展过程中可能具有抑制作用,其机制可能主要与雌激素受体ERβ有关。
[Abstract]:Objective to investigate the expression of sulfate-transferase gene 1A3 (SULT1A3) and estrogen receptor subtype (ER 伪 -ER 尾) in uterine leiomyoma and its correlation with the pathogenesis of uterine leiomyoma. Methods from October 2013 to June 2015, 30 patients with uterine leiomyoma or hysteromyomectomy and 10 patients with uterine prolapse were selected from Shengjing Hospital affiliated to China Medical University. No other uterine lesions, Paraffin tissue specimens of patients undergoing hysterectomy. Immunohistochemical method was used to detect the expression and difference of SULT1A3 and ER 伪 -ER 尾 in 30 cases of uterine leiomyoma and 10 cases of normal uterine myometrium. Results the expression of SULT1A3 in uterine leiomyoma was significantly lower than that in extracapsular myometrium and normal myometrium (P0.05), while the expression of estrogen receptor ER 伪 -ER 尾 was significantly increased (P0.05). There was significant negative correlation between SULT1A3 and ER 尾 in uterine leiomyoma (P0.05), but no correlation with ER 伪 (P0.05). Conclusion SULT1A3 may inhibit the occurrence and development of uterine leiomyoma, and its mechanism may be related to estrogen receptor ER 尾.
【作者单位】：中国医科大学附属盛京医院妇产科;厦门市第二医院妇产科;
【分类号】：R737.33

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