血清GA、ADP、RBP4、Hcy与妊娠糖尿病胰岛素抵抗的相关性研究
发布时间：2018-08-30 09:02
【摘要】：目的探讨糖化白蛋白(GA)、脂联素(ADP)、视黄醇结合蛋白4(RBP4)、同型半胱氨酸(Hcy)与妊娠糖尿病(GDM)胰岛素抵抗的关系。方法选取2014年7月—2015年7月保定市妇幼保健院GDM患者80例(GDM组)、正常孕妇80例(正常妊娠组)及正常非妊娠期妇女80例(正常非妊娠组),比较3组血清GA、ADP、RBP4、Hcy水平,分析GA、ADP、RBP4、Hcy与GDM孕妇胰岛素抵抗的关系。结果 GDM组血清GA、RBP4、Hcy水平分别为(18.36±0.98)%、(42.98±2.28)mg/L、(22.36±2.58)μg/L,均显著高于正常妊娠组的(14.22±2.05)%、(34.22±3.48)mg/L、(11.25±2.98)μg/L以及正常非妊娠组的(14.36±2.69)%、(30.02±2.96)mg/L、(11.02±2.79)μg/L,而ADP水平为(4.23±1.42)mg/L,显著低于正常妊娠组的(9.23±2.58)mg/L以及正常非妊娠组的(9.78±2.69)mg/L(P0.05),正常妊娠组RBP4水平高于正常非妊娠组(P0.05)。GDM组空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)高于正常妊娠组及正常非妊娠组(P0.05),正常妊娠组FPG、FINS、HOMA—IR高于正常非妊娠组,但差异无统计学意义(P0.05)。经Pearson相关因素分析可知,GA、RBP4、Hcy与FPG、FINS、HOMA-IR水平呈正相关(P0.05),而ADP与FPG、FINS、HOMA-IR水平呈负相关(P0.05)。GA、ADP、RBP4、Hcy联合诊断GDM的ROC曲线下面积(AUC)为0.902,大于单一指标,灵敏度、特异度分别为87.2%、88.6%,均高于单一指标。结论血清GA、ADP、RBP4、Hcy水平异常与GDM患者胰岛素抵抗有密切的关系,通过检测血清GA、ADP、RBP4、Hcy水平能快速、有效地对GDM作出诊断,联合多指标检测可提高诊断灵敏度和特异度。
[Abstract]:Objective to investigate the relationship between glycosylated albumin (GA), adiponectin (ADP), retinol binding protein 4 (RBP4) homocysteine (Hcy) and insulin resistance of (GDM) in gestational diabetes mellitus. Methods from July 2014 to July 2015, 80 GDM patients (GDM group), 80 normal pregnant women (normal pregnancy group) and 80 normal non-pregnant women (normal non-pregnant group) in Baoding City Maternal and Child Health Care Hospital were selected and the serum GA,ADP,RBP4,Hcy levels were compared among the three groups. To analyze the relationship between GA,ADP,RBP4,Hcy and insulin resistance in GDM pregnant women. 缁撴灉 GDM缁勮娓匞A,RBP4,Hcy姘村钩鍒嗗埆涓，
本文编号：2212614
[Abstract]:Objective to investigate the relationship between glycosylated albumin (GA), adiponectin (ADP), retinol binding protein 4 (RBP4) homocysteine (Hcy) and insulin resistance of (GDM) in gestational diabetes mellitus. Methods from July 2014 to July 2015, 80 GDM patients (GDM group), 80 normal pregnant women (normal pregnancy group) and 80 normal non-pregnant women (normal non-pregnant group) in Baoding City Maternal and Child Health Care Hospital were selected and the serum GA,ADP,RBP4,Hcy levels were compared among the three groups. To analyze the relationship between GA,ADP,RBP4,Hcy and insulin resistance in GDM pregnant women. 缁撴灉 GDM缁勮娓匞A,RBP4,Hcy姘村钩鍒嗗埆涓，
本文编号：2212614
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