S100A14与RAGE在子宫颈鳞癌组织中的表达及临床意义
[Abstract]:Objective: to investigate the expression and clinical significance of calcium binding protein (S100A14) and advanced glycation end product receptor (RAGE) in cervical squamous cell carcinoma (SCC). Methods: immunohistochemical method was used to detect the expression of S100A14 and RAGE in 76 cases of cervical intraepithelial neoplasia (CIN) and 102 cases of cervical squamous cell carcinoma (SCC), and to explore the relationship between the expression of S100A14 and RAGE and the clinicopathological indexes of cervical carcinoma. The expression of S100A14, RAGE and prognosis were analyzed in 102 patients with cervical squamous cell carcinoma. Results both the expression of S100A14 and RAGE in normal cervix and cervix squamous cell carcinoma showed an increasing trend (P0.05). The expression of S100A14 and RAGE in cervical squamous cell carcinoma was related to FIGO stage, lymph node metastasis and deep interstitial infiltration (P0.05). The expression of rage was related to tumor size, but not to differentiation, but S100A14 was related to differentiation. There was a positive correlation between S100A14 and RAGE expression in cervical squamous cell carcinoma (P0.05). The survival rate of S100A14 and RAGE high expression group was significantly lower than that of low expression group (P0.05). Conclusion both the expression of S100A14 and RAGE are up-regulated in cervical squamous cell carcinoma, which is related to the occurrence, invasion and metastasis of squamous cell carcinoma of the cervix, and may be a new target for the treatment of cervical squamous cell carcinoma and a powerful index for evaluating the prognosis.
【作者单位】: 青岛大学附属医院妇科;
【分类号】:R737.33
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8 顾U喲,
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