S100A14与RAGE在子宫颈鳞癌组织中的表达及临床意义

发布时间：2018-08-30 11:31

【摘要】：目的:探讨钙结合蛋白S100A14与晚期糖基化终产物受体(RAGE)在宫颈鳞癌组织中的表达及临床意义。方法:免疫组化法检测S100A14与RAGE在23例正常宫颈、76例宫颈上皮内瘤变(CIN)及102例宫颈鳞癌组织中的表达,探讨S100A14与RAGE表达与宫颈癌临床病理指标的关系。对102例宫颈鳞癌患者进行术后随访,分析S100A14与RAGE表达与预后的关系。结果:S100A14和RAGE在正常宫颈到宫颈鳞癌组织中的表达均呈递增趋势(P0.05)。宫颈鳞癌中S100A14和RAGE表达与FIGO分期、淋巴结转移和深层间质浸润有关(P0.05);RAGE表达与肿瘤大小有关,与分化无关;但S100A14与分化有关,与肿瘤大小无关。S100A14与RAGE在宫颈鳞癌中表达呈正相关(P0.05)。S100A14和RAGE高表达组分别与低表达组相比较,生存率均明显降低(P0.05)。结论:S100A14与RAGE在宫颈鳞癌中均表达上调,其表达升高与宫颈鳞癌的发生、浸润及转移相关,可能成为治疗宫颈鳞癌的新靶点和评估预后的有力指标。
[Abstract]:Objective: to investigate the expression and clinical significance of calcium binding protein (S100A14) and advanced glycation end product receptor (RAGE) in cervical squamous cell carcinoma (SCC). Methods: immunohistochemical method was used to detect the expression of S100A14 and RAGE in 76 cases of cervical intraepithelial neoplasia (CIN) and 102 cases of cervical squamous cell carcinoma (SCC), and to explore the relationship between the expression of S100A14 and RAGE and the clinicopathological indexes of cervical carcinoma. The expression of S100A14, RAGE and prognosis were analyzed in 102 patients with cervical squamous cell carcinoma. Results both the expression of S100A14 and RAGE in normal cervix and cervix squamous cell carcinoma showed an increasing trend (P0.05). The expression of S100A14 and RAGE in cervical squamous cell carcinoma was related to FIGO stage, lymph node metastasis and deep interstitial infiltration (P0.05). The expression of rage was related to tumor size, but not to differentiation, but S100A14 was related to differentiation. There was a positive correlation between S100A14 and RAGE expression in cervical squamous cell carcinoma (P0.05). The survival rate of S100A14 and RAGE high expression group was significantly lower than that of low expression group (P0.05). Conclusion both the expression of S100A14 and RAGE are up-regulated in cervical squamous cell carcinoma, which is related to the occurrence, invasion and metastasis of squamous cell carcinoma of the cervix, and may be a new target for the treatment of cervical squamous cell carcinoma and a powerful index for evaluating the prognosis.
【作者单位】：青岛大学附属医院妇科;
【分类号】：R737.33

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