TCF7L2基因多态性与多囊卵巢综合征易感性的meta分析

发布时间：2018-08-31 14:09

【摘要】：目的：探讨TCF7L2rs7903146、rs290487基因多态性与多囊卵巢综合征易感性的的关联强度。方法：制定检索式,并通过计算机检索PubMed、EMbase、Cochrane Library以及中国生物医学文献数据库、中国知网、万方数据库公开发表的关于TCF7L2的基因多态性与多囊卵巢综合征易感性的相关文献。检索时间自建库起至2014年3月1日。对相关文献进行筛选、质量评价、异质性评价并提取相关病例对照研究基本资料,利用Revman5.2软件进行meta分析,计算合并的比值比(odds ratio,OR)及其95%可信区间(confidence interval,CI)分析两者间的关联强度。结果：共纳入文献8篇,其中5篇涉及研究位点rs7903146,4篇研究rs290487位点,前者共包括病例组1661例及对照组2866例,后者病例组1544例,对照组1134例。根据异质性分析结果使用随机效应模型或固定效应模型,合并数据结果示rs7903146基因多态性与多囊卵巢综合征易感性的风险模型中均提示两者间无相关性(OR:0.98.1.10:95%CI:0.85-0.91to1.13.1.41).而rs290487基因位点携带C等位基因者PCOS患病风险增加(OR:1.11-1.46:95%CI:0.94-1.14to1.31-1.89)。结论：TCF7L2rs7903146基因多态性与多囊卵巢综合征的遗传易感性不存在相关性。TCF7L2rs290487基因多态性中携带C等位基因者多囊卵巢综合征患病风险增高,对于疾病今后的预防、诊断及基因靶向治疗提供了依据。
[Abstract]:Objective: To investigate the association between polymorphism of TCF7L2rs7903146, rs290487 gene and susceptibility to polycystic ovary syndrome (PCOS).
METHODS: PubMed, EMbase, Cochrane Library and Chinese Biomedical Literature Database, China HowNet and Wanfang Database were searched by computer. The relevant literatures about TCF7L2 gene polymorphism and susceptibility to polycystic ovary syndrome were published. The retrieval time was from the establishment of the database to March 1, 2014. Screening, quality evaluation, heterogeneity evaluation and extracting the basic data of case-control studies were performed. Revman 5.2 software was used for meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were calculated to analyze the correlation strength between the two.
RESULTS: A total of 8 articles were included, 5 of which involved rs7903146 and 4 of which involved rs290487. The former included 1661 cases in the case group and 2866 cases in the control group. The latter included 1544 cases in the case group and 1134 cases in the control group. There was no correlation between sex and polycystic ovary syndrome (OR: 0.98.1.10:95% CI: 0.85-0.91 to 1.13.1.41). The risk of PCOS was increased in rs290487 locus carriers (OR: 1.11-1.46:95% CI: 0.94-1.14 to 1.31-1.89).
Conclusion: The polymorphism of TCF7L2rs7903146 gene is not associated with the genetic susceptibility to polycystic ovary syndrome.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.75

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