神经细胞黏附因子在子宫腺肌病病灶中的表达及意义

发布时间：2018-09-01 17:29

【摘要】：目的:检测神经细胞黏附因子(NCAM)在子宫腺肌病在位内膜及异位内膜中的表达,探讨NCAM在子宫腺肌病发病中的作用。方法:采用免疫组化法检测40例子宫腺肌病标本在位内膜与异位内膜组织中NCAM的表达情况(分泌期与增生期各20期),并与20例正常子宫内膜标本进行比较。采用0~10级NRS疼痛评价量表对子宫腺肌病患者痛经程度进行评分,并与相应患者NCAM染色情况进行比较。结果:NCAM在40例子宫腺肌病在位内膜和异位内膜及19例正常内膜腺上皮中均有表达,1例正常内膜无表达,间质中无表达。异位内膜组织中NCAM表达明显高于在位内膜和正常对照组(P0.01)。在位内膜组织分泌期NCAM表达含量高于增生期(P0.05)。子宫腺肌病异位病灶NCAM表达与患者痛经程度呈正相关(r=0.84,P0.01)。结论:NCAM可能参与子宫腺肌病的发病过程,并参与子宫腺肌病痛经的发生发展,但具体分子机制尚需进一步研究。
[Abstract]:Aim: to detect the expression of neuronal adhesion factor (NCAM) in eutopic endometrium and ectopic endometrium of adenomyosis and to explore the role of NCAM in the pathogenesis of adenomyosis. Methods: immunohistochemical method was used to detect the expression of NCAM in eutopic and ectopic endometrium in 40 cases of adenomyosis (20 cases in secretory phase and 20 stage in proliferative phase), and compared with 20 cases of normal endometrium. The degree of dysmenorrhea in patients with adenomyosis was evaluated by NRS pain evaluation scale of grade 0 and 10, and compared with NCAM staining of corresponding patients. Results in 40 cases of adenomyosis eutopic and ectopic endometrium and 19 cases of normal endometrial glandular epithelium, there was no expression of 1 normal endometrium and no expression in stroma. The expression of NCAM in ectopic endometrium was significantly higher than that in eutopic endometrium and normal control group (P0.01). The expression of NCAM in secretory phase of eutopic endometrium was higher than that in proliferative phase (P0.05). The expression of NCAM in ectopic lesions of adenomyosis was positively correlated with the degree of dysmenorrhea (r = 0.84, P 0.01). ConclusionNCAM may be involved in the pathogenesis of adenomyosis and the occurrence and development of dysmenorrhea of adenomyosis, but the molecular mechanism needs further study.
【作者单位】：山东大学附属省立医院妇科;
【基金】：国家自然科学基金资助项目(No:81200426) 山东省自然科学基金资助项目(No.ZR2013HM060;No:ZR2011HQ046) 山东省科技发展计划(No:2014GSF118048)
【分类号】：R711.71

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