FOXP3、B7-H4在卵巢子宫内膜异位囊肿组织中的表达及意义

发布时间：2018-09-02 09:03

【摘要】：目的观察叉头状转录因子3(FOXP3)、B7同源体4(B7-H4)在卵巢子宫内膜异位囊肿组织中的表达情况,并探讨其意义。方法选取行手术治疗的卵巢子宫内膜异位囊肿患者30例(囊肿组)、卵巢癌患者20例(癌症组)及卵巢良性肿瘤患者20例(良性组),术中留取组织标本,采用免疫组化法检测各组织中FOXP3及B7-H4的表达。结果囊肿组FOXP3和B7-H4阳性表达率分别为76.7%(23/30)、80.0%(24/30),癌症组FOXP3和B7-H4阳性表达率分别为85.0%(17/20)、90.0%(18/20),良性组FOXP3和B7-H4阳性表达率分别为0、5.0%(1/20)。囊肿组及癌症组病变组织FOXP3、B7-H4阳性表达率均高于良性组(P均0.05),囊肿组与癌症组病变组织FOXP3、B7-H4阳性表达率差异均无统计学意义(P均0.05)。相关分析显示,卵巢子宫内膜异位囊肿组织中FOXP3、B7-H4表达呈正相关(r=0.915,P0.05)。结论 FOXP3和B7-H4在子宫内膜异位症内异症组织中表达增加,二者均与卵巢子宫内膜异位囊肿的发生发展有关。
[Abstract]:Objective to investigate the expression and significance of forkhead transcription factor 3 (FOXP3) B7 homologue 4 (B7-H4) in ovarian endometriosis cysts. Methods 30 cases of ovarian endometriosis cysts (cysts group), 20 cases of ovarian cancer (cancer group) and 20 cases of benign ovarian tumors (benign group) were selected. Immunohistochemical method was used to detect the expression of FOXP3 and B7-H4 in various tissues. Results the positive rates of FOXP3 and B7-H4 were 76.7% (23 / 30), 80.0% (24 / 30), 85.0% (17 / 20) and 90.0% (18 / 20), respectively. The positive rates of FOXP3 and B7-H4 in benign group were 0% (1 / 20). The positive expression rate of FOXP3,B7-H4 in cyst group and cancer group was higher than that in benign group (P 0.05). There was no significant difference in positive expression rate of FOXP3,B7-H4 between cyst group and cancer group (P 0.05). Correlation analysis showed that the expression of FOXP3,B7-H4 was positively correlated in ovarian endometriosis (r 0.915 P 0.05). Conclusion the expression of FOXP3 and B7-H4 in endometriosis is increased, both of which are related to the occurrence and development of ovarian endometriosis cyst.
【作者单位】：江苏省中医院;
【基金】：江苏省自然科学基金资助项目(BK20151573)
【分类号】：R711.71

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