2002-2014年河南省HIV暴露婴幼儿母婴阻断效果研究

发布时间：2018-09-06 16:02

【摘要】：目的了解不同时期河南省HIV暴露婴幼儿母婴传播及生存情况,分析母婴传播的有关因素。方法通过预防艾滋病、梅毒及乙肝母婴传播信息系统,收集不同工作时期HIV感染孕产妇及所分娩婴儿的有关干预信息,包括孕产妇围生期母婴阻断服务、婴幼儿HIV感染及生存状况等,采用Logistic回归对影响HIV母婴传播的有关因素进行分析。结果截止2014年12月底分娩的1 673例婴幼儿中,存活满18月龄婴儿共1 515人(90.56%),其中检测阳性婴儿64人(3.83%),检测阴性婴儿1 451人(86.73%),已经死亡的婴儿101人(6.04%),失访婴儿57人(3.40%),婴儿累计死亡率为6.24%,存活婴儿累计母婴传播率为4.22%,校正累计艾滋病母婴传播率6.25%。产妇孕早期接受PMTCT服务(OR=0.23,95%CI:0.07~0.72),产妇及婴儿药物阻断(OR=0.46,95%CI:0.23~0.95),婴幼儿采人工喂养(0R=0.09,95%CI:0.02~0.35)是艾滋病母婴传播的保护因素,产妇分娩过程不安全助产(0R=3.52,95%CI:1.49~8.27)是其危险因素。结论艾滋病暴露婴幼儿的母婴传播率及死亡率均较高,应进一步加强孕产妇及婴儿的随访管理,同时进一步完善预防艾滋病母婴传播的综合干预措施。
[Abstract]:Objective to investigate the status of mother-to-child transmission and survival of infants exposed to HIV in Henan Province in different periods, and to analyze the related factors of mother-to-child transmission. Methods through the information system for prevention of HIV / AIDS, syphilis and hepatitis B transmission from mother to child, the information about the intervention of pregnant women infected with HIV and their babies delivered in different working periods was collected, including the interruption of maternal and child delivery services during perinatal period. HIV infection and survival status of infants were analyzed by Logistic regression. Results of the 1,673 infants and children who gave birth at the end of December 2014, A total of 1,515 infants (90.56%) survived over 18 months of age, of whom 64 (3.83%) were tested positive, 1,451 (86.73%) were negative, 101 (6.04%) were dead, 57 (3.40%) were lost, the cumulative infant mortality rate was 6.24%, and the cumulative mother to child transmission of surviving infants was 6.24%. The rate was 4.22. The cumulative rate of mother-to-child transmission of AIDS was 6.25. PMTCT service (OR=0.23,95%CI:0.07~0.72), drug blocking (OR=0.46,95%CI:0.23~0.95), artificial feeding (0RR0. 09% CI: 0. 02% 0. 35) were the protective factors for mother-to-child transmission of HIV. Unsafe delivery attended delivery (0 RV 3. 52% 95 CI: 1. 498.27) was the risk factor. Conclusion the rate of mother-to-child transmission and mortality of infants exposed to AIDS are high. The follow-up management of pregnant women and infants should be further strengthened and the comprehensive intervention measures for prevention of mother-to-child transmission of AIDS should be further improved.
【作者单位】：河南省疾病预防控制中心;
【基金】：河南省医学科技攻关计划项目(201602308) 国家”十二五”科技重大专项(2012ZX10004905)
【分类号】：R714.251

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