骨桥蛋白和CD133在卵巢上皮性癌组织中的表达及意义

发布时间：2018-09-07 10:14

【摘要】：目的运用免疫组化法检测骨桥蛋白(osteopotin,OPN)和CD133在卵巢上皮性癌组织中的表达,并分析它们与临床病理参数的相关性及生物学意义。方法采用免疫组化法检测OPN和CDl33在卵巢良性、交界性、恶性肿瘤组织及正常卵巢组织中的表达。结果(1)OPN和CD133的阳性表达在正常对照组和良性肿瘤与卵巢交界性肿瘤、卵巢癌组之间差异有统计学意义(P0.05),正常组与良性肿瘤组差异无统计学意义(P0.05);(2)OPN、CD133阳性表达与卵巢肿瘤的临床分期、分化程度和是否淋巴结转移相关,差异有统计学意义(P0.05),与上皮性肿瘤中的组织学不同类型无关,差异无统计学意义(P0.05);(3)采用配对资料相关分析发现,OPN与CD133的表达之间有明显正相关性(r=0.525,P0.05)。结论OPN、CD133在卵巢上皮性癌中呈高表达,并与临床分期、分级、淋巴结转移有关,与组织学分类无相关性。在卵巢癌组织中OPN的表达与CD133呈正相关,提示OPN与CD133的协同作用可能对卵巢癌进展起重要作用。
[Abstract]:Objective to detect the expression of osteopontin (osteopotin,OPN) and CD133 in epithelial ovarian carcinoma by immunohistochemical method, and to analyze their correlation with clinicopathological parameters and their biological significance. Methods Immunohistochemical method was used to detect the expression of OPN and CDl33 in benign, borderline, malignant and normal ovarian tissues. Results (1) the positive expression of OPN and CD133 was found in normal control group and benign tumor and ovarian borderline tumor. There was significant difference between ovarian cancer group and benign tumor group (P0.05). There was no significant difference between normal group and benign tumor group (P0.05); (2) positive expression of OPN,CD133 was correlated with clinical stage, differentiation degree and lymph node metastasis of ovarian tumor. The difference was statistically significant (P0.05), but not related to different types of histology in epithelial tumors (P0.05); (3). The correlation analysis of pairing data showed that there was a significant positive correlation between the expression of); (and CD133 (rn 0.525 P 0.05). Conclusion OPN,CD133 is highly expressed in epithelial ovarian carcinoma, which is related to clinical stage, grade and lymph node metastasis, but not to histological classification. The expression of OPN was positively correlated with CD133 in ovarian cancer tissues, suggesting that the synergistic effect of OPN and CD133 might play an important role in the progression of ovarian cancer.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.31

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