年轻隐匿型原发性卵巢功能不全患者的试管受精妊娠结局研究

发布时间：2018-09-08 10:54

【摘要】：目的比较病理性卵巢储备功能下降(DOR)即年轻隐匿型原发性卵巢功能不全(POI)患者与生理性DOR(高龄)患者的试管受精(IVF)助孕治疗的妊娠结局,以期为临床工作提供指导。方法回顾性分析2015年1月—2016年12月在广东省妇幼保健院生殖中心行IVF-ET治疗的符合纳入标准的257例患者的275例IVF-ET治疗周期(其中POI组77个周期,高龄组198个周期)的临床、实验室及随访资料(包括妊娠结局等)。结果与高龄组相比,POI组的年龄较小,抗苗勒氏激素(AMH)较低,不孕时间较短,取卵数、成熟卵子数、优质胚胎数较少,但胚胎种植率、生化妊娠率及临床妊娠率较高,自然流产率较低,差异均有统计学意义(P0.05)。结论尽管年轻隐匿型POI妇女卵巢储备功能已显著降低,卵巢产生的卵子数量已减少,但其质量并未下降,仍可获得较好的IVF妊娠结局。
[Abstract]:Objective to compare the pregnancy outcome of IVF (IVF) assisted pregnancy therapy in patients with primary ovarian insufficiency (POI) and aged patients with primary ovarian insufficiency (POI) with pathological ovarian reserve dysfunction (DOR) in order to provide guidance for clinical work. Methods from January 2015 to December 2016, 275 patients with IVF-ET (77 cycles in POI group and 198 cycles in senior age group) who were treated with IVF-ET in the reproductive center of Guangdong Maternal and Child Health Hospital were analyzed retrospectively. Laboratory and follow-up data (including pregnancy outcome). Results compared with the old age group, the age of the control group was lower, the time of infertility was shorter, the number of eggs taken, the number of mature eggs and the number of high-quality embryos were less, but the implantation rate, biochemical pregnancy rate and clinical pregnancy rate were higher. Natural abortion rate was lower, the differences were statistically significant (P0.05). Conclusion although the ovarian reserve function and the number of eggs produced in the ovaries have decreased significantly in the young occult POI women, the quality of the ovaries has not decreased, and a better outcome of IVF pregnancy can be obtained.
【作者单位】：广东省妇幼保健院;
【基金】：广东省自然科学基金(2016A030310318)——端粒与卵巢储备下降及其IVF/ICSI妊娠结局相关性的初步研究
【分类号】：R714.8

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