女性体重指数与H-P-O轴驱动性的相关性分析
发布时间:2018-09-09 08:53
【摘要】:目的:探讨体重指数(BMI)增加对女性下丘脑-垂体-卵巢轴驱动性的影响。方法:按BMI将患者分为对照组(18.5BMI22.9kg/m2,162例)、超重组(23.0BMI24.9kg/m2,112例)和肥胖组(BMI≥25.0kg/m2,122例),采取放射免疫法测定FSH、LH、E2基础数值,比较3组患者的月经周期变化。结果:(1)超重组患者的FSH、LH、E2基础值分别为(6.32±1.71)m IU/ml、(4.21±1.64)m IU/ml、(123.96±49.81)pmol/ml,肥胖组分别为(5.97±1.48)m IU/ml、(3.97±1.69)m IU/ml、(112.46±43.3)pmol/ml,两组均较对照组明显减低(P0.05);(2)超重组与肥胖组患者的月经紊乱比例分别为46.4%和55.7%,明显高于对照组(17.9%)(P0.05);(3)超重组和肥胖组的FSH/LH比值分别为1.73±0.77、1.78±0.86,呈FSH与LH比值倒置状态。结论:BMI增加的患者可能减慢下丘脑GnRH脉冲发生器,使H-P-O轴驱动减弱,继发性引起垂体促性腺激素释放减慢,导致卵泡发育迟缓、月经周期延长、黄体功能不足、自然流产甚至不孕症。
[Abstract]:Objective: to investigate the effect of increasing body mass index (BMI) on the axis drive of hypothalamus-pituitary-ovary in women. Methods: according to BMI, the patients were divided into three groups: control group (18.5BMI22.9kg/m2162), superrecombinant (23.0BMI24.9kg/m2112) and obese (BMI 鈮,
本文编号:2231905
[Abstract]:Objective: to investigate the effect of increasing body mass index (BMI) on the axis drive of hypothalamus-pituitary-ovary in women. Methods: according to BMI, the patients were divided into three groups: control group (18.5BMI22.9kg/m2162), superrecombinant (23.0BMI24.9kg/m2112) and obese (BMI 鈮,
本文编号:2231905
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