不同程度病变宫颈组织miR-424表达水平及其临床意义
发布时间：2018-09-15 06:26
【摘要】：目的探讨微小RNA(miR)-424在宫颈上皮内瘤变(CIN)和宫颈癌患者宫颈组织中的表达情况及其临床意义。方法齐齐哈尔医学院附属第一医院就诊并最终获得宫颈组织病理学诊断的40~69岁女性患者,收集宫颈组织;采用实时荧光定量PCR检测不同病变程度宫颈组织中miR-424的相对表达水平并进行比较。结果共收集129例不同程度病变患者的正常和病变宫颈组织样本(CINⅠ组25例,CINⅡ组30例,CINⅢ组28例,宫颈癌组46例)。不同病变程度宫颈组织中miR-424的表达差异有统计学意义(F=47.009,P=0.000),且随着病变程度的增加,miR-424的表达水平呈下降趋势。miR-424高表达所占比例与宫颈组织病变程度相关(χ2=8.377,P=0.039),而与人乳头瘤病毒(HPV)感染情况不相关。结论miR-424在不同病变宫颈的表达水平存在差异,随着宫颈病变程度的加重,其表达水平呈降低趋势,并且宫颈病变程度影响miR-424的表达水平。
[Abstract]:Objective to investigate the expression and clinical significance of RNA (miR)-424 in cervical tissues of patients with cervical intraepithelial neoplasia (CIN) and cervical carcinoma. Methods 4069 year old female patients with cervical histopathology were collected from the first affiliated Hospital of Qiqihar Medical College. Real-time fluorescence quantitative PCR was used to detect the relative expression of miR-424 in cervical tissues with different pathological degrees. Results the samples of normal and pathological cervical tissues were collected from 129 patients with different degrees of pathological changes (CIN 鈪，
本文编号：2244049
[Abstract]:Objective to investigate the expression and clinical significance of RNA (miR)-424 in cervical tissues of patients with cervical intraepithelial neoplasia (CIN) and cervical carcinoma. Methods 4069 year old female patients with cervical histopathology were collected from the first affiliated Hospital of Qiqihar Medical College. Real-time fluorescence quantitative PCR was used to detect the relative expression of miR-424 in cervical tissues with different pathological degrees. Results the samples of normal and pathological cervical tissues were collected from 129 patients with different degrees of pathological changes (CIN 鈪，
本文编号：2244049
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