子宫腺肌病患者子宫内膜组织HGF、C-Met、MMP-9和TIMP-1表达变化及意义

发布时间：2018-09-17 15:37

【摘要】：目的探讨肝细胞生长因子(HGF)及其受体原癌基因(C-Met)、基质金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制因子1(TIMP-1)在子宫腺肌病发生、发展中的作用。方法选择子宫腺肌病患者30例(观察组),因子宫肌瘤行子宫切除术的患者30例(对照组)。采用免疫组化SP法检测观察组在位及异位内膜、对照组内膜组织HGF、C-Met、MMP-9和TIMP-1,HGF、C-Met、MMP-9及TIMP-1之间的关系采用多元统计相关分析。结果观察组异位内膜、在位内膜及对照组内膜组织、HGF、C-Met、MMP-9表达依次升高,TIMP-1依次降低;两两比较,P均0.01。观察组异位内膜中HGF、C-Met、MMP-9两两均呈正相关,并均与TIMP-1呈负相关(P均0.01)。观察组在位内膜及对照组内膜组织HGF、C-Met、MMP-9两两均呈正相关,C-Met、MMP-9与TIMP-1均呈负相关(P均0.01);HGF与TIMP-1无关(P0.05)。结论子宫腺肌病患者异位内膜组织HGF、C-Met、MMP-9降低,TIMP-1升高,各指标间均具有相关性,可能与疾病的发生、发展有关。
[Abstract]:Objective to investigate the role of hepatocyte growth factor (HGF) and its receptor proto-oncogene (C-Met), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the development of adenomyosis. Methods 30 patients with adenomyosis and 30 patients with uterine myoma underwent hysterectomy (control group). The eutopic and ectopic endometrium in the observation group were detected by immunohistochemical SP method, and the relationship among HGF,C-Met,MMP-9, TIMP-1,HGF,C-Met,MMP-9 and TIMP-1 in the control group was analyzed by multivariate statistical correlation analysis. Results the expression of HGFC-MMP 9 in ectopic endometrium, eutopic endometrium and control group was increased and TIMP-1 decreased in turn, compared with each other (P 0.01). There was a positive correlation between HGF,C-Met,MMP-9 and TIMP-1 in the ectopic endometrium in the observation group (all P 0.01). There was a positive correlation between HGF,C-Met,MMP-9 and TIMP-1 in eutopic endometrium of observation group and control group (P0.05). Conclusion HGF,C-Met,MMP-9 in ectopic endometrium of patients with adenomyosis may be related to the occurrence and development of the disease.
【作者单位】：武汉大学人民医院;
【分类号】：R711.71

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