生殖道人乳头瘤病毒与其它病原体感染关系的探讨

发布时间：2018-09-18 14:49

【摘要】：目的：探讨女性生殖道人乳头状瘤病毒(Human Papillomaviruses, HPV)感染与生殖道其它常见病原体感染的关系。方法：收集2011年8月至2013年8月在新疆医科大学第二附属医院妇产科住院患者HPV分型一种亚型或多种亚型呈阳性的患者73例,HPV分型亚型呈阴性患者80例,两组患者均进行沙眼衣原体、解脲支原体、细菌性阴道病、假丝酵母菌和阴道毛滴虫的检测,统计分析检测结果,了解生殖道HPV感染与其它病原体感染有无相关性。结果：HPV呈阳性的73例患者中,15例为HPV多种亚型混合感染,其余58例为单一的HPV亚型感染,其中中高危型HPV阳性者占71.2%,检出率较高的为HPV52型、16型、53型、66型；低危型HPV阳性者占8.2%,主要有6型、11型、43型。HPV阳性组和HPV阴性组与生殖道其它病原体感染单因素比较：解脲支原体感染与HPV感染具有显著性意义(X2=5.19,P0.05),其它病原体感染与HPV感染不具有显著性意义。Logistic回归分析结果显示：生殖道解脲支原体感染与HPV感染具有相关性(OR=2.401,95%CI为1.173～4.914,P0.05),解脲支原体是HPV感染的危险因素；生殖道沙眼衣原体、细菌性阴道病、假丝酵母菌、阴道毛滴虫感染与HPV感染无相关性(P均0.05)。结论：生殖道解脲支原体感染与HPV感染具有相关性,解脲支原体感染可增加HPV感染；沙眼衣原体、细菌性阴道病、假丝酵母菌、阴道毛滴虫感染与HPV感染无明显相关性。
[Abstract]:Objective: to investigate the relationship between human papillomavirus (Human Papillomaviruses, HPV) infection in female genital tract and other common pathogens in genital tract. Methods: from August 2011 to August 2013, a total of 73 patients with positive subtype or subtypes of HPV were selected from the second affiliated Hospital of Xinjiang Medical University, Department of Gynecology and Obstetrics. Chlamydia trachomatis, Ureaplasma Urealyticum, bacterial vaginosis, Candida cerevisiae and Trichomonas vaginalis were detected in both groups. Results among 73 cases with positive HPV, 15 cases were mixed infection of HPV subtype, the other 58 cases were single HPV subtype infection. The high risk HPV positive cases accounted for 71.2%. Low risk type HPV positive group accounted for 8.2%. There were 6 type 11 type 43. HPV-positive group and HPV negative group compared with the single factor of other pathogens infection in the reproductive tract: Ureaplasma Urealyticum infection and HPV infection had significant significance (X2P 5.19 P 0.05), other pathogens infection had significant significance (X2P 5.19 P 0.05), and other pathogens were infected with Ureaplasma Urealyticum infection and HPV infection. Logistic regression analysis showed that Ureaplasma Urealyticum infection was correlated with HPV infection (OR=2.401,95%CI = 1.173, 4.914, P0.05). Ureaplasma Urealyticum was the risk factor of HPV infection. There was no correlation between chlamydia trachomatis, bacterial vaginosis, Candida cerevisiae, trichomonas vaginalis infection and HPV infection (all P 0.05). Conclusion: Ureaplasma Urealyticum infection is related to HPV infection, Ureaplasma Urealyticum infection can increase HPV infection, but Chlamydia trachomatis, bacterial vaginosis, Candida cerevisiae, Trichomonas vaginalis infection and HPV infection have no significant correlation.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.31

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