不同方法治疗妊娠期外阴阴道念珠菌感染患者的临床疗效对比

发布时间：2018-09-18 20:38

【摘要】：目的:探讨不同方法治疗妊娠期外阴阴道念珠菌感染患者的临床疗效。方法:选取2013年10月至2015年10月于我院接受治疗的妊娠期外阴阴道念珠菌感染患者110例,按照治疗方法的不同分为单用组和联用组,每组各55例。其中单用组每晚睡前用小苏打液冲洗阴道外阴后于阴道内放置克霉唑栓,联用组在此基础上加用硝酸咪康唑霜涂擦瘙痒处。两组患者均持续治疗1周。随访患者直至胎儿出生,记录两组患者的临床疗效、复发率、不良反应发生率和新生儿情况并进行对比分析。结果:两组患者经过治疗后,其外阴瘙痒、外阴灼痛和分泌物增多的症状均得到改善,且联合者患者改善得更显著(P0.05);联合组患者的治疗总有效率为92.7%,明显高于单用组的67.2%,差异有统计学意义(P0.05);治疗过程中,两组均有1例患者出现不良反应,但对病程影响不大,且两组患者均顺利分娩出健康新生儿。结论:克霉唑栓联合硝酸咪康唑霜治疗妊娠期外阴阴道念珠菌感染能够明显改善患者临床症状,不影响孕妇分娩和胎儿发育,安全性较高,在临床上值得推广。
[Abstract]:Objective: to investigate the clinical effect of different methods on vulvovaginal candida infection during pregnancy. Methods: 110 cases of vulvovaginal candida infection in pregnancy received treatment in our hospital from October 2013 to October 2015 were divided into single group and combined group according to the different treatment methods, 55 cases in each group. The vaginal vulva was washed with baking soda solution before bedtime and clotrimazole suppository was placed in the vagina of the single use group and the miconazole nitrate cream was used to rub the itching place in the combined use group. The patients in both groups were treated continuously for 1 week. The clinical efficacy, recurrence rate, adverse reaction rate and neonatal status of the two groups were recorded and analyzed. Results: after treatment, the symptoms of pruritus, burning pain and increased secretion of vulva were improved in both groups. The total effective rate of the combined group was 92.7, which was significantly higher than that of the single-use group (P 0.05). In the course of treatment, one patient in both groups had adverse reactions, but had little effect on the course of disease. All the patients in both groups gave birth to healthy newborns. Conclusion: clotrimazole suppository combined with miconazole nitrate cream in the treatment of vulvovaginal candida infection during pregnancy can obviously improve the clinical symptoms of the patients without affecting the delivery and fetal development of pregnant women.
【作者单位】：恩施州中心医院中医部(恩施州民族医院)妇产科;
【分类号】：R711.31

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