绝经前后女性维生素D营养状况及其与血脂代谢相关性研究
发布时间：2018-10-08 20:58
【摘要】：目的描述绝经前后女性血清维生素D水平的分布特点并探讨其影响因素;初步探讨绝经前、围绝经期、绝经后女性血清维生素D与血脂之间的关系。方法采用横断面调查研究方法,以2014年10月-11月在安徽医科大学第一附属医院健康体检中心进行体检的35岁以上健康女性为研究对象。使用自行设计的调查问卷进行问卷调查,并收集其体格检查资料和临床生化指标。问卷调查内容包括一般人口学特征等基本信息,生活习惯,月经生育史,既往疾病史等;体格检查包括身高、体重、血压等;临床生化指标包括:25(OH)D、FBG、TC、TG、LDL-C、HDL-C。应用SPSS16.0软件包进行t检验、单因素方差分析、偏相关分析和二元Logistic回归分析。结果共获取符合条件的研究对象302例,平均年龄为48.1±7.6岁。48%的女性为家庭妇女,文化程度总体较低,74.8%的调查者自述经济状况中等。绝经前、围绝经期以及绝经后女性分别占35.1%、30.5%以及34.4%。研究对象的血清25(OH)D水平的均值为(15.21±4.76)ng/m L。维生素D水平正常者仅有2例(0.66%),不足者44例(14.57%),缺乏者256例(84.77%)。绝经前、围绝经期、绝经后女性组血清25(OH)D水平依次升高,组间差异有统计学意义(P=0.013),但不同年龄、职业、学历、经济状况的人群,组间血清25(OH)D水平均无统计学差异;是否饮酒、不同睡眠时间、是否经常进行户外锻炼以及不同体力活动强度组间的血清25(OH)D水平也均无统计学差异;服用钙剂者血清25(OH)D水平高于未服用者,差异有统计学意义(P=0.003),但不同饮食习惯组间血清25(OH)D水平无统计学差异。二元Logistic回归分析显示是否服用钙剂以及年龄是维生素D是否缺乏的独立影响因素。绝经前、围绝经期、绝经后三组SBP、FBG、TC、LDL-C水平依次升高,差异有统计学意义(P0.05)。偏相关分析显示绝经后女性血清25(OH)D水平与TG水平呈负相关(r=-0.203,P=0.045);围绝经期女性血清25(OH)D水平与HDL-C水平呈负相关(r=-0.274,P=0.010)。按照血脂水平不同分组比较,302例研究对象组间血清25(OH)D水平无统计学差异,但按月经情况进行分层后,绝经后女性不同TG水平组间血清25(OH)D水平差异有统计学意义(P=0.030)。二元非条件Logistic回归分析显示血清25(OH)D是TG的独立影响因素。结论绝经前后女性普遍存在维生素D营养缺乏,年龄、服用钙剂是维生素D水平的影响因素。绝经前、围绝经期女性血清25(OH)D与血脂代谢之间无相关性,绝经后女性低的维生素D水平可能对TG产生不利影响。
[Abstract]:Objective to study the relationship between serum vitamin D and blood lipid in premenopausal, perimenopausal and postmenopausal women. Methods A cross-sectional investigation was conducted on healthy women over 35 years old who were examined in the Health examination Center of the first affiliated Hospital of Anhui Medical University from October to November 2014. The self-designed questionnaire was used to collect the data of physical examination and clinical biochemical index. The contents of the questionnaire included general demographic characteristics, life habits, menstrual history, history of illness, etc. Physical examination included height, weight, blood pressure, and clinical biochemical indexes included: 1. T test, single factor analysis of variance, partial correlation analysis and binary Logistic regression analysis were carried out with SPSS16.0 software package. Results A total of 302 eligible subjects were obtained. The average age was 48.1 卤7.6 years old. 48% of the women were housewives, and 74.8% of the respondents with lower education level reported moderate self-reported economic status. Before menopause, 35. 1% and 34. 4% of peri-menopausal and postmenopausal women accounted for 35. 5% and 34. 4% respectively. The mean value of serum 25 (OH) D level was (15.21 卤4.76) ng/m / L. There were only 2 cases (0.66%) with normal vitamin D level, 44 cases (14.57%) with deficiency and 256 cases (84.77%) with deficiency. The serum 25 (OH) D level of premenopausal, peri-menopausal and postmenopausal women increased in turn, and the difference was statistically significant (P < 0.013), but there was no significant difference in serum 25 (OH) D levels among groups with different age, occupation, educational background and financial status. There was also no significant difference in serum 25 (OH) D levels between the groups with different sleep time, whether or not exercising outdoors and with different physical activity intensity. The serum 25 (OH) D level of patients taking calcium was higher than that of those who did not take calcium. The difference was statistically significant (P0. 003), but there was no significant difference in serum 25 (OH) D level among different dietary habits. Binary Logistic regression analysis showed that calcium intake and age were independent factors for vitamin D deficiency. The levels of SBP,FBG,TC,LDL-C in premenopausal, peri-menopausal and postmenopausal groups increased in turn, and the difference was statistically significant (P0.05). Partial correlation analysis showed that there was a negative correlation between serum 25 (OH) D level and TG level in postmenopausal women (r = 0.203), and a negative correlation between serum 25 (OH) D level and HDL-C level in postmenopausal women (r = -0.274). There was no significant difference in serum 25 (OH) D level among 302 subjects according to the blood lipid level, but there was significant difference in serum 25 (OH) D level among postmenopausal women with different TG levels after menstrual stratification (P0. 030). Binary non-conditional Logistic regression analysis showed that serum 25 (OH) D was an independent factor for TG. Conclusion Vitamin D deficiency is common in postmenopausal women. Age and calcium are the influencing factors of vitamin D level in premenopausal and postmenopausal women. There was no correlation between serum 25 (OH) D and lipid metabolism in postmenopausal women. Low vitamin D level in postmenopausal women might have a negative effect on TG.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R711
本文编号：2258241
[Abstract]:Objective to study the relationship between serum vitamin D and blood lipid in premenopausal, perimenopausal and postmenopausal women. Methods A cross-sectional investigation was conducted on healthy women over 35 years old who were examined in the Health examination Center of the first affiliated Hospital of Anhui Medical University from October to November 2014. The self-designed questionnaire was used to collect the data of physical examination and clinical biochemical index. The contents of the questionnaire included general demographic characteristics, life habits, menstrual history, history of illness, etc. Physical examination included height, weight, blood pressure, and clinical biochemical indexes included: 1. T test, single factor analysis of variance, partial correlation analysis and binary Logistic regression analysis were carried out with SPSS16.0 software package. Results A total of 302 eligible subjects were obtained. The average age was 48.1 卤7.6 years old. 48% of the women were housewives, and 74.8% of the respondents with lower education level reported moderate self-reported economic status. Before menopause, 35. 1% and 34. 4% of peri-menopausal and postmenopausal women accounted for 35. 5% and 34. 4% respectively. The mean value of serum 25 (OH) D level was (15.21 卤4.76) ng/m / L. There were only 2 cases (0.66%) with normal vitamin D level, 44 cases (14.57%) with deficiency and 256 cases (84.77%) with deficiency. The serum 25 (OH) D level of premenopausal, peri-menopausal and postmenopausal women increased in turn, and the difference was statistically significant (P < 0.013), but there was no significant difference in serum 25 (OH) D levels among groups with different age, occupation, educational background and financial status. There was also no significant difference in serum 25 (OH) D levels between the groups with different sleep time, whether or not exercising outdoors and with different physical activity intensity. The serum 25 (OH) D level of patients taking calcium was higher than that of those who did not take calcium. The difference was statistically significant (P0. 003), but there was no significant difference in serum 25 (OH) D level among different dietary habits. Binary Logistic regression analysis showed that calcium intake and age were independent factors for vitamin D deficiency. The levels of SBP,FBG,TC,LDL-C in premenopausal, peri-menopausal and postmenopausal groups increased in turn, and the difference was statistically significant (P0.05). Partial correlation analysis showed that there was a negative correlation between serum 25 (OH) D level and TG level in postmenopausal women (r = 0.203), and a negative correlation between serum 25 (OH) D level and HDL-C level in postmenopausal women (r = -0.274). There was no significant difference in serum 25 (OH) D level among 302 subjects according to the blood lipid level, but there was significant difference in serum 25 (OH) D level among postmenopausal women with different TG levels after menstrual stratification (P0. 030). Binary non-conditional Logistic regression analysis showed that serum 25 (OH) D was an independent factor for TG. Conclusion Vitamin D deficiency is common in postmenopausal women. Age and calcium are the influencing factors of vitamin D level in premenopausal and postmenopausal women. There was no correlation between serum 25 (OH) D and lipid metabolism in postmenopausal women. Low vitamin D level in postmenopausal women might have a negative effect on TG.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R711
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相关期刊论文 前2条
1 张艳玲;马书赫;张栩;于春晓;赵家军;;山东地区中老年人群维生素D缺乏情况及其与高血压的关系[J];山东医药;2014年14期
2 Lidija Klampfer;;Vitamin D and colon cancer[J];World Journal of Gastrointestinal Oncology;2014年11期
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