GnRH拮抗剂和GnRH激动剂短方案在卵巢功能低下患者超促排卵中的应用比较

发布时间：2018-10-09 21:26

【摘要】：目的探讨GnRH括抗剂和GnRH激动剂短方案对卵巢功能低下患者行体外受精超促排卵治疗的临床结局的比较。方法回顾性分析2015年1月~2016年5月在本中心采用GnRH-ant方案和GnRH-a短方案促排卵行IVF-ET治疗患者120例的临床资料,随机分成A组与B组,均为60个周期,比较两组的Gn用量,HCG日相关激素水平,获卵率、受精率、优胚率等实验室结果及临床妊娠率。结果 A组的Gn总用量,HCG日雌二醇(E_2)水平,获卵率,优胚率,妊娠率显著高于B组,差异有统计学意义(P0.05)。HCG日LH和P值的水平,A组明显低于B组,差异有统计学意义(P0.05),而两者在受精率及卵裂率,差异无统计学意义(P0.05)。结论对卵巢功能低下患者,GnRH拮抗剂方案较常规激动剂短方案能提高获卵率、优胚率和临床妊娠率,无疑是一种较可靠的用药方案。
[Abstract]:Objective to compare the clinical outcome of GnRH and GnRH agonists in the treatment of ovulation hyperstimulation by in vitro fertilization in patients with ovarian dysfunction. Methods from January 2015 to May 2016, the clinical data of 120 patients who were treated with IVF-ET by GnRH-ant regimen and GnRH-a short protocol were analyzed retrospectively. The patients were randomly divided into group A and group B for 60 cycles. The results of laboratory and clinical pregnancy rate were compared between the two groups in terms of Gn dosage and HCG-related hormone levels, egg acquisition rate, fertilization rate, embryo rate and so on. Results the total dosage of Gn in group A was significantly higher than that in group B (P 0.05). The level of LH and P in group A was significantly lower than that in group B. The difference was statistically significant (P0.05), but there was no significant difference in fertilization rate and cleavage rate (P0.05). Conclusion the GnRH antagonist regimen in patients with hypofunctional ovary can increase the rate of oocyte acquisition, embryo and clinical pregnancy, which is a reliable regimen.
【作者单位】：江苏省常州市妇幼保健院生殖中心;
【分类号】：R714.8

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