孕妇高危型人乳头瘤病毒载量和持续时间与宫颈病变的关系

发布时间：2018-10-11 11:46

【摘要】：目的探讨孕妇从妊娠初期至分娩后宫颈高危型人乳头瘤病毒(HR-HPV)感染的载量与持续时间与其相关宫颈病变的关系。方法 1 368例孕妇在末次月经至分娩后1年取宫颈分泌物,采用杂交捕获第二代技术检测HR-HPV DNA,同时行宫颈细胞学检查和组织病理学检查。结果 1 368例孕妇妊娠初期HR-HPV感染率为26.5%(362/1 368);其中21~40岁组高于其他年龄组(P0.05)。感染者中发生宫颈病变者57例,患病率为15.7%(57/362)。其中宫颈上皮内瘤变(CIN)52例,宫颈癌(ICC)5例。ICC和各期CIN的HR-HPV载量比较,差异无统计学意义(P0.05)。CIN孕妇分娩后1年HR-HPV转阴率为82.7%(43/52)。分娩后42 d HR-HPV载量较妊娠各期明显减少(P0.05),分娩后3个月和1年较妊娠各期明显减少(P0.01)。结论HR-HPV的载量与宫颈病变的严重程度无关,分娩后HR-HPV自然转阴率较高,其感染载量逐渐减少直到消除。
[Abstract]:Objective to investigate the relationship between the load and duration of high-risk human papillomavirus (HR-HPV) infection and cervical lesions in pregnant women from the beginning of pregnancy to postpartum. Methods 1,368 pregnant women were collected from cervical secretions from the last menstruation to one year after delivery. The second generation hybridization capture technique was used to detect HR-HPV DNA, and cervical cytology and histopathology were performed simultaneously. Results the infection rate of HR-HPV in the first trimester of 1 368 pregnant women was 26. 5% (362 / 1 368), among which the 21 ~ 40 years old group was higher than other age group (P0.05). There were 57 cases of cervical lesions in infected patients, the prevalence rate was 15.7% (57 / 362). There were 52 cases of cervical intraepithelial neoplasia (CIN) and 5 cases of cervical cancer (ICC). There was no significant difference in HR-HPV load between ICC and CIN (P0.05). The HR-HPV negative rate was 82.7% (43 / 52) in 1 year after delivery of). CIN pregnant women. The HR-HPV load at 42 days after delivery was significantly lower than that in each pregnancy stage (P0.05), and at 3 months and 1 year after delivery, it was significantly lower than that in each pregnancy period (P0.01). Conclusion the load of HR-HPV is not related to the severity of cervical lesions. The natural negative rate of HR-HPV is higher after delivery, and the load of HR-HPV gradually decreases until it is eliminated.
【作者单位】：重庆华西妇产医院妇产科;重庆市中医院;
【基金】：重庆市九龙坡区科委社会发展类基金资助项目(201307)
【分类号】：R737.33

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