密度梯度离心法与直接上游法优化处理精液对宫腔内人工授精临床妊娠率的影响

发布时间：2018-10-12 07:23

【摘要】：目的:应用密度梯度离心法和直接上游法处理不明原因不孕和轻度精液异常患者的精液,比较两种方法对宫腔内人工授精(IUI)临床妊娠率的影响。方法:回顾性分析2013年1月至2014年12月期间,在我中心进行促排卵+IUI的571个周期患者,统计其精液优化处理方法和临床妊娠率。结果:总体临床妊娠率为密度梯度离心法(17.8%)显著高于直接上游法(11.4%)(P0.05);不明原因不孕组的临床妊娠率为密度梯度离心法(33.7%)显著高于直接上游法(20.3%)(P0.05);轻度精液异常组的临床妊娠率为密度梯度离心法(11.6%)显著高于直接上游法(7.6%)(P0.05)。结论:密度梯度离心法相对直接上游法能有效提高因不明原因不孕和轻度精液异常患者IUI的临床妊娠率。
[Abstract]:Objective: to study the effect of density gradient centrifugation and direct upstream method on the clinical pregnancy rate of intrauterine insemination (IUI) in patients with unexplained infertility and mild abnormal semen. Methods: during the period from January 2013 to December 2014, 571 cycles of ovulation stimulating IUI were analyzed in our center, and their semen optimal treatment methods and clinical pregnancy rate were analyzed. Results: the total clinical pregnancy rate was significantly higher by density gradient centrifugation (17.8%) than that by direct upstream method (11.4%) (P0.05), the clinical pregnancy rate of unexplained infertility group (33.7%) was significantly higher than that of direct upstream method (20.3%), and the clinical pregnancy rate was significantly higher in mild semen abnormality group (P0.05). The pregnancy rate was significantly higher by density gradient centrifugation (11.6%) than that by direct upstream (7.6%) (P0.05). Conclusion: the density gradient centrifugation method can effectively improve the clinical pregnancy rate of IUI in patients with unexplained infertility and mild semen abnormality compared with direct upstream method.
【作者单位】：广东省妇幼保健院生殖健康与不孕症科;广东省妇幼保健院妇科;
【基金】：广东省医学科研基金立项课题资助项目(编号:A2014095)
【分类号】：R714.8

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