辅助生殖患者在黄体支持中的超说明书用药调查

发布时间：2018-10-12 08:13

【摘要】：目的:调查辅助生殖技术(ART)患者的黄体支持超说明书用药情况,为规范黄体支持用药提供参考。方法:采用回顾性调查方法,抽取2012年7月1日-12月31日广州某院生殖医学中心采取辅助生殖技术患者的黄体支持用药医嘱,比较超说明书用药组与说明书用药组患者的妊娠率、抱婴率、流产率与胎儿出生缺陷情况。结果:共有2 039个周期符合纳入标准,医嘱9 213条。孕酮类、雌激素类、促性腺素类超说明书用药的发生率分别为34.39%(2 820/8 200)、100%(577/577)、63.99%(279/436),总体发生率39.90%(3 676/9 213),超说明书用药类型主要包括超适应证、超给药方式、超剂量、超用药频次和存在禁忌证。超说明书用药组与说明书用药组的妊娠率有统计学差异(46.90%vs 38.00%,P0.01),而两组的流产率、抱婴率、胎儿出生缺陷情况均无统计学差异(P0.05)。结论:该院ART患者的黄体支持药物超说明书用药情况普遍,需加强超说明书用药的规范管理,保护患者用药有效安全的同时规避医师的职业风险。
[Abstract]:Objective: to investigate the drug usage of luteal support hyperinstruction in (ART) patients with assisted reproductive technology and to provide reference for regulating luteal support drug use. Methods: by retrospective investigation, luteal support drug prescriptions of patients with assisted reproductive technology were collected from reproductive medicine center of Guangzhou hospital from July 1 to December 31, 2012. The pregnancy rate, infantile rate, abortion rate and fetal birth defect were compared between the superscript group and the instruction group. Results: a total of 2 039 cycles met the inclusion criteria, with 9 213 orders. The incidences of progesterone, estrogen and gonadotropin were 34.39% (2820 / 8 200), 100% (577 / 577), 63.99% (279 / 436), respectively. The overall incidence rate was 39.90% (3 676 / 9 213). There was significant difference in the pregnancy rate between the overdose group and the instruction group (46.90%vs 38.00, P0.01), but there was no significant difference in abortion rate, infantile rate and fetal birth defect between the two groups (P0.05). Conclusion: luteal support drugs are commonly used in patients with ART in our hospital. It is necessary to strengthen the standard management of drug use in order to protect the effective safety of drug use and avoid the occupational risk of doctors.
【作者单位】：广州医科大学附属第三医院药学部;广州医科大学;广州医科大学附属第三医院生殖医学中心;
【分类号】：R714.8

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