宫颈癌术前新辅助化疗反应性对预后影响的meta分析

发布时间：2018-10-16 10:59

【摘要】：目的：了解新辅助化疗反应性对宫颈癌患者远期预后的影响。方法：电子检索PubMed、MEDLINE、Web of Knowledge、Google、中国知网数据库、维普科技期刊数据库搜索文献，根据异质性检测决定使用固定或随机效应模型进行效应量比值比（OR）合并统计，用RevMan.5.2统计学软件进行统计处理。结果：共有14篇文章共1326名患者纳入，化疗有效反应率波动在39.8%-97.3%（实体瘤评价标准评价）及27.6%、28.6%（手术标本病理诊断评价），2-year PFS/OS效应量比值比OR分别为4.67（95%CI3.35-6.77；Z=8.68P=0.00）、4.39（95%CI2.53-7.61；Z=5.26P=0.00），，5-year PFS/OS效应量比值比OR分别为5.36（95%CI3.59-7.99；Z=8.23P=0.00）、5.80（95%CI3.83-8.79；Z=8.30P=0.00）。X2检验及I2检验提示各纳入研究无显著异质性，漏斗图提示无显著发表偏倚，通过改变效应统计模型、去除大样本进行敏感性分析，提示该meta分析结果稳定。结论：宫颈癌术前新辅助化疗有效的化疗反应性可改善远期预后。
[Abstract]:Objective: to investigate the effect of neoadjuvant chemotherapeutic reactivity on long-term prognosis in patients with cervical cancer. Methods: PubMed,MEDLINE,Web of Knowledge,Google, China knowledge Network Database and Wiper Science and Technology Journal Database were searched electronically. According to the heterogeneity test, fixed or random effect models were used to combine the ratio of effect volume to (OR). RevMan.5.2 statistical software was used to deal with the statistics. Results: a total of 1326 patients were included in 14 articles. The effective response rate of chemotherapy varied from 39.8% to 97.3% (evaluation criteria for solid tumors) and 27.62.6% (pathological diagnosis of surgical specimens). The ratio of 2-year PFS/OS effect to OR was 4.67 (95CI3.35-6.77Z8.68P0.00) and 4.39 (95CI2.53-7.61), respectively. Z=5.26P=0.00), the ratio of 5-year PFS/OS effect volume to OR was 5.36 (95CI3.59-7.99) and 5.80 (95CI3.83-8.79ZH 8.30P0.00) respectively. X2 test and I2 test showed that there was no significant heterogeneity in each study, and funnel diagram showed no significant bias. The sensitivity analysis was carried out by changing the statistical model of effect and removing large samples. These results suggest that the meta analysis results are stable. Conclusion: preoperative neoadjuvant chemotherapy can improve the long-term prognosis of cervical cancer.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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