不同促排卵方案的辅助生殖效果比较

发布时间：2018-10-16 14:44

【摘要】：目的:探索不同促排卵方案用于治疗多囊卵巢综合症(PCOS)所致不孕的临床效果。方法:选取我院2011年1月至2013年12月诊疗的PCOS不孕症患者198例,随机分为A、B、C三组,分别为64例、68例、66例。A组给予克罗米芬(CC)治疗;B组给予人绝经期促性腺激素(HMG)治疗;C组给予克罗米芬联合人绝经期促性腺激素治疗。观察比较三组患者的排卵率、妊娠率及雌二醇(E2)、卵泡期黄体生成素(LH)及血清睾酮(T)水平。结果:C组E2水平最高达到865.67±387.31pg/L,B组均低于A组与C组(tAB=3.271,tBC=3.913,P0.05;tAC=1.567,P0.05)。LH值:A组LH水平明显低于B、C组,差异有统计学意义(tAB=2.312,tAC=2.710,P0.05)。T值:三组之间的T水平,差异不具有统计学意义(tAB=0.843,tAC=1.241,tBC=1.397,P0.05)。A组40个周期排卵率61.50%,妊娠率为15.6%;B组35个排卵周期排卵率69.5%,妊娠率为19.1%,C组35个排卵周期排卵率83.51%,妊娠率为30.3%。C组的排卵率均高于A、B组,差异具有统计学意义(χ2AC=5.231,χ2BC=4.561,P均0.05)。C组的妊娠率也要由于A、B两组,差异有统计学意义(χ2AC=4.231,χ2BC=3.861,P均0.05)。结论:采用CC联合HMG治疗PCOS致不孕症是一个有效促排卵方案,进一步的研究仍需大样本的临床随机对照实验的随访进一步研究证实该方案的有效性和安全性。
[Abstract]:Objective: to explore the clinical effect of different ovulation promotion protocols in the treatment of infertility caused by polycystic ovary syndrome (PCOS). Methods: 198 patients with PCOS infertility diagnosed and treated in our hospital from January 2011 to December 2013 were randomly divided into three groups. Group A was treated with clomiphene (CC), group B with human menopausal gonadotropin (HMG) and group C with clomiphene combined with human menopausal gonadotropin. The ovulation rate, pregnancy rate, estradiol (E _ 2), luteinizing hormone (LH) and serum testosterone (T) levels in the three groups were observed and compared. Results: the highest level of E _ 2 in group C was 865.67 卤387.31 PG / L, which was lower than that in group A and C (tAB=3.271,tBC=3.913,P0.05;tAC=1.567,P0.05). LH value: the level of LH in group A was significantly lower than that in group C). The difference was statistically significant (tAB=2.312,tAC=2.710,P0.05). T value: t level between three groups). There was no significant difference (tAB=0.843,tAC=1.241,tBC=1.397,P0.05). A group 40 cycles ovulation rate 61.50, pregnancy rate 15.6B group 35 ovulation cycle ovulation rate 69.5%, pregnancy rate 19.1C group 35 ovulation cycle ovulation rate 83.51%, pregnancy rate 30.30.C group ovulation rate were higher than AB group. The difference was statistically significant (蠂 ~ 2AC = 5.231, 蠂 ~ 2BC = 4.561P all 0.05). The pregnancy rate of the two groups was also significantly higher than that of the control group (蠂 ~ 2AC = 4.231, 蠂 ~ 2BC = 3.861P, P < 0.05), and the difference was also significant between the two groups (蠂 ~ 2AC = 4.231, 蠂 ~ 2BC = 3.861, P < 0.05). Conclusion: CC combined with HMG is an effective ovulation-promoting regimen for infertility induced by PCOS. Further study needs to be carried out in a large clinical randomized controlled trial to confirm the efficacy and safety of the protocol.
【作者单位】：吉林大学第二医院;
【分类号】：R714.8

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