拉贝洛尔对中重度妊娠期高血压疾病患者心肾功能及妊娠结局的影响及机制
发布时间：2018-10-17 12:08
【摘要】：目的探讨拉贝洛尔对中重度妊娠期高血压疾病患者心肾功能及妊娠结局的影响及机制。方法选择中重度妊娠期高血压疾病患者120例,随机分为观察组与对照组各60例。对照组给予25%硫酸镁溶液60 m L+5%葡萄糖注射液500 m L静脉滴注,1次/d;甲基多巴250 mg/次口服,2次/d。观察组给予硫酸镁治疗,方法同对照组;另外加拉贝拉尔50 mg+5%葡萄糖注射液500 m L静脉滴注,1次/d。两组均治疗1周。对比两组治疗前后肾功能指标[血清胱抑素C(Cys C)、尿微量白蛋白(m ALB)、24 h尿蛋白]、心功能指标[肌钙蛋白T(c Tn T)/血浆钠尿肽(BNP)]及炎性因子[血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)]水平、平均动脉压(MAP)、妊娠结局。结果治疗后两组血清Cys C、m ALB、24 h尿蛋白、血清c Tn T、BNP、CRP、TNF-α水平与治疗前比较,P均0.05;治疗后观察组以上指标与对照组比较,P均0.05。两组产后出血、羊水Ⅲ度浑浊、终止妊娠、胎儿窘迫发生率及新生儿出生5 min Apgar评分比较,P均0.05。结论拉贝洛尔可减轻中重度妊娠期高血压疾病患者心肾功能损伤,改善妊娠结局;其机制可能与下调患者体内血清炎性因子水平有关。
[Abstract]:Objective to investigate the effect and mechanism of Labe lol on heart and kidney function and pregnancy outcome in patients with moderate and severe hypertensive disorder complicating pregnancy. Methods 120 patients with moderate and severe hypertensive disorder complicating pregnancy were randomly divided into two groups: the observation group (n = 60) and the control group (n = 60). The control group was given 60% magnesium sulfate solution 60 mL 5% glucose injection 500ml intravenously once a day, and methyldopa 250 mg/ orally twice a day. The observation group was treated with magnesium sulfate in the same way as the control group, in addition, Galabella 50 mg 5% glucose injection 500ml intravenously, once a day. Both groups were treated for 1 week. Renal function index [serum cystatin C (Cys C), urine microalbumin (m ALB), 24 h urine protein], cardiac function index [troponin T (c Tn T) / plasma natriuretic peptide (BNP)] and inflammatory factor [serum C-reactive protein (CRP), tumor necrosis factor 伪 (TNF- 伪)] were compared before and after treatment. Mean arterial pressure (MAP),) pregnancy outcome. Results after treatment, the levels of serum Cys Cam ALB,24 h urine protein, serum c Tn TNPP, CRPNP TNF- 伪 in the two groups were compared with those before treatment (P 0.05), and the above indexes in the observation group were higher than those in the control group (P 0.05). There were significant differences in postpartum hemorrhage, 鈪，
本文编号：2276609
[Abstract]:Objective to investigate the effect and mechanism of Labe lol on heart and kidney function and pregnancy outcome in patients with moderate and severe hypertensive disorder complicating pregnancy. Methods 120 patients with moderate and severe hypertensive disorder complicating pregnancy were randomly divided into two groups: the observation group (n = 60) and the control group (n = 60). The control group was given 60% magnesium sulfate solution 60 mL 5% glucose injection 500ml intravenously once a day, and methyldopa 250 mg/ orally twice a day. The observation group was treated with magnesium sulfate in the same way as the control group, in addition, Galabella 50 mg 5% glucose injection 500ml intravenously, once a day. Both groups were treated for 1 week. Renal function index [serum cystatin C (Cys C), urine microalbumin (m ALB), 24 h urine protein], cardiac function index [troponin T (c Tn T) / plasma natriuretic peptide (BNP)] and inflammatory factor [serum C-reactive protein (CRP), tumor necrosis factor 伪 (TNF- 伪)] were compared before and after treatment. Mean arterial pressure (MAP),) pregnancy outcome. Results after treatment, the levels of serum Cys Cam ALB,24 h urine protein, serum c Tn TNPP, CRPNP TNF- 伪 in the two groups were compared with those before treatment (P 0.05), and the above indexes in the observation group were higher than those in the control group (P 0.05). There were significant differences in postpartum hemorrhage, 鈪，
本文编号：2276609
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