唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局分析

发布时间：2018-10-17 20:36

【摘要】：目的探讨妊娠中期唐氏筛查低风险但单项指标人绒毛膜促性腺激素(HCG)水平异常增高妊娠妇女的妊娠结局,为唐氏筛查单项指标HCG水平异常进行临床咨询提供理论依据。方法选择2012年10月—2013年12月南京医科大学附属无锡妇幼保健院妊娠中期唐氏筛查低风险的单胎妊娠妇女212例为研究对象,其中单项指标HCG水平增高的妊娠妇女112例为试验组,HCG水平正常的妊娠妇女100例为对照组,随访其妊娠结局,观察两组异常妊娠情况(包括胎膜早破、巨大儿、胎儿畸形、胎盘异常)。结果试验组巨大儿、胎儿畸形、胎盘异常发生率均高于对照组(P0.05)。两组胎膜早破发生率比较,差异无统计学意义(P0.05)。试验组5例胎儿畸形中3例为胎儿心脏畸形、1例为胎儿肺囊腺瘤、1例经无创基因筛查提示唐氏综合征经羊水穿刺证实后引产;9例胎盘异常中6例为胎盘粘连、2例胎盘形态异常、1例胎盘早剥。结论妊娠中期唐氏筛查HCG水平增高与巨大儿、胎儿异常及胎盘异常等不良妊娠结局相关。
[Abstract]:Objective to investigate the pregnancy outcome of pregnant women with low risk of Down's screening but abnormal level of human chorionic gonadotropin (HCG) in middle pregnancy, and to provide theoretical basis for clinical consultation on abnormal HCG level in Down's screening. Methods from October 2012 to December 2013, 212 single pregnancy women with low risk were selected from Wuxi Maternal and Child Health Hospital affiliated to Nanjing Medical University. One hundred and twelve pregnant women with high HCG level were treated as experimental group and 100 pregnant women with normal HCG level as control group. The pregnancy outcome was followed up and abnormal pregnancy was observed in two groups (including premature rupture of fetal membrane, macrosomia, fetal malformation). Abnormal placenta). Results the incidence of macrosomia, fetal malformation and placenta abnormality in the experimental group was higher than that in the control group (P0.05). There was no significant difference in the incidence of premature rupture of membranes between the two groups (P0.05). In the trial group, 3 cases were fetal heart malformation, 1 case was fetal pulmonary cystadenoma, 1 case was induced by non-invasive gene screening, 6 cases were placenta adhesion and 2 cases were placental abnormality. Placental abruption was found in 1 case. Conclusion the increase of HCG level in Down's screening in the second trimester is related to the abnormal pregnancy outcome such as macrosomia, fetal abnormality and placental abnormality.
【作者单位】：南京医科大学附属无锡妇幼保健院;
【分类号】：R714.2

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