妊娠期肝内胆汁淤积症与妊娠期高胆汁酸血症456例临床分析

发布时间：2018-10-25 14:21

【摘要】：目的:探讨妊娠期肝内胆汁淤积症(ICP)与妊娠期高胆汁酸血症(HP)的差异。方法:选择重庆医科大学附属第一医院的ICP孕妇374例和HP孕妇82例,并选择同期分娩正常孕妇300例作为对照组。对其产前各项生化检测指标和妊娠结局进行回顾性分析。结果:(1)ICP孕妇与正常孕妇比较,其剖宫产率、早产率和羊水粪染率的差异有统计学意义(P0.01)。HP孕妇组的剖宫产率和羊水粪染率明显高于正常孕妇组(P0.05)。但HP孕妇组的剖宫产率和早产率显著低于ICP孕妇组。(2)HP孕妇血清TBA水平与其妊娠结局无明显相关性。(3)当孕妇TBA≥40μmol/L时,ICP孕妇的剖宫产、早产和羊水粪染的发生率显著高于孕妇血清TBA在10-40μmol/L者(P0.05)。(4)黄疸型的ICP孕妇的早产率和羊水粪染率显著高于无黄疸型ICP孕妇(P0.05)。(5)ICP孕妇血清ALT≥250U/L者早产发生率显著高于ALT250U/L者(P0.05)。结论:妊娠期肝内胆汁淤积症与妊娠期高胆汁酸血症是不同的,妊娠期高胆汁酸血症母儿预后较好。妊娠期肝内胆汁淤积症病情严重程度与母体血清总胆汁酸、胆红素和转氨酶水平相关。
[Abstract]:Objective: to investigate the difference between (ICP) and (HP) in intrahepatic cholestasis of pregnancy. Methods: 374 ICP pregnant women and 82 HP pregnant women were selected from the first affiliated Hospital of Chongqing Medical University, and 300 normal pregnant women were selected as the control group. The antepartum biochemical indexes and pregnancy outcome were analyzed retrospectively. Results: (1) the cesarean section rate, premature delivery rate and amniotic fluid fecal staining rate of ICP pregnant women were significantly higher than those of normal pregnant women (P0.05). However, the rate of cesarean section and premature delivery in HP group was significantly lower than that in ICP group. (2) there was no significant correlation between the serum TBA level of pregnant women with HP and their pregnancy outcome. (3) when TBA 鈮，

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