甲状腺自身抗体与复发性流产的相关性分析

发布时间：2018-10-25 20:59

【摘要】：目的研究分析甲状腺自身抗体抗甲状腺过氧化物酶抗体(TPOAb)与复发性流产的相关性,为临床诊断复发性流产寻找客观的数据指标。方法选择2012年3月至2014年5月在该院进行体检的妇产科门诊甲状腺功能正常的孕早期妇女1 016例作为研究对象,筛选出其中的90例流产患者分成两组,原发性流产组60例,复发性流产组30例,另选90例体检健康的育龄女性作为对照组,统计并对比各组的TPOAb阳性例数,计算比率;记录各组TPOAb水平,同时分析TPOAb与复发性流产的相关性。结果复发性流产组的TPOAb阳性率为46.67%,显著高于原发性流产组的25.00%,以及对照组的4.44%;同时原发性流产组的TPOAb阳性率亦显著高于对照组,差异均有统计学意义(均P0.05)。复发性流产组的TPOAb水平显著高于原发性流产组和对照组的水平;同时原发性流产组的TPOAb浓度水平亦显著高于对照组的水平,差异均有统计学意义(均P0.05)。随访不良妊娠发生情况,以复发性流产为不良妊娠事件,并根据Spearman法分析相关性可知,随着TPOAb水平的增加,复发性流产的发生率增高,二者之间呈正相关(r=0.764,P=0.000)。结论监测患者TPOAb水平,可较好地呈现复发性流产的症状情况。
[Abstract]:Objective to study the correlation between thyroid autoantibody (TPOAb) and recurrent abortion and to find objective data for clinical diagnosis of recurrent abortion. Methods from March 2012 to May 2014, 1016 pregnant women with normal thyroid function in gynecology and obstetrics outpatient clinic were selected as the study objects. 90 of them were divided into two groups, 60 cases of primary abortion group. Thirty cases of recurrent abortion group and 90 healthy women of childbearing age were selected as control group. The positive cases of TPOAb in each group were counted and compared, and the ratio of TPOAb was calculated. The levels of TPOAb were recorded and the correlation between TPOAb and recurrent abortion was analyzed. Results the positive rate of TPOAb in recurrent abortion group was 46.67, which was significantly higher than that in primary abortion group (25.00) and control group (4.44%). At the same time, the positive rate of TPOAb in primary abortion group was significantly higher than that in control group, the difference was statistically significant (P0.05). The level of TPOAb in recurrent abortion group was significantly higher than that in primary abortion group and control group, and the level of TPOAb in primary abortion group was significantly higher than that in control group (P0.05). According to the analysis of Spearman method, the incidence of recurrent abortion increased with the increase of TPOAb level, and there was a positive correlation between them (r = 0.764P = 0.000). Conclusion Monitoring the level of TPOAb can better present the symptoms of recurrent abortion.
【作者单位】： 贵州省兴义市人民医院内分泌科;
【分类号】：R714.21

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