黄连素与二甲双胍治疗多囊卵巢综合征的随机对照试验系统评价
发布时间：2018-10-29 16:16
【摘要】：目的系统评价黄连素对比二甲双胍治疗多囊卵巢综合征(PCOS)的有效性和安全性。方法计算机检索PUBMED、Cochrane数据库、中国知网、维普和万方数据平台等,从建库至2015年2月,选择黄连素对比二甲双胍治疗PCOS的随机对照试验(RCT)。按Cochrane系统评价方法评价质量,用Rev Man 5.3软件进行统计分析。结果共纳入3个RCT,合计197例PCOS患者,试验组98例,对照组99例。Meta分析结果显示:黄连素在降低腰臀比、空腹胰岛素、总胆固醇及低密度脂蛋白胆固醇水平方面的疗效优于二甲双胍,在降低体质指数、空腹血糖、稳态模型评估胰岛素抵抗指数、三酰甘油、总睾酮水平及升高高密度脂蛋白胆固醇水平方面的疗效与二甲双胍相当。结论相比二甲双胍,黄连素更适合治疗中心性肥胖、空腹胰岛素水平明显升高的胰岛素抵抗者、高胆固醇血症及高低密度脂蛋白胆固醇水平者和不能耐受二甲双胍胃肠道不良反应的PCOS患者。鉴于本系统评价纳入研究较少且样本含量较小,因此未来尚需开展更多大样本、多中心、设计严格的高质量RCT加以验证。
[Abstract]:Objective to evaluate the efficacy and safety of berberine versus metformin in the treatment of polycystic ovary syndrome (PCOS). Methods the PUBMED,Cochrane database, China Zhiwang, Weip and Wanfang data platform were searched by computer. From the establishment of the database to February 2015, a randomized controlled trial (RCT).) with berberine versus metformin was used to treat PCOS. According to the evaluation method of Cochrane system, the statistical analysis was carried out with Rev Man 5.3 software. Results A total of 197 cases of PCOS were included in 3 RCT, patients, 98 cases in the trial group and 99 cases in the control group. The results of Meta analysis showed that berberine decreased waist-to-hip ratio, fasting insulin, and insulin, Total cholesterol and low density lipoprotein cholesterol levels were superior to metformin in lowering body mass index, fasting blood glucose, homeostasis model to evaluate insulin resistance index, triacylglycerol. The effects of total testosterone and elevated high density lipoprotein cholesterol were comparable to metformin. Conclusion compared with metformin, berberine is more suitable for the treatment of insulin resistance patients with central obesity and elevated fasting insulin level. Patients with hypercholesterolemia and high and low density lipoprotein cholesterol levels and PCOS patients who could not tolerate the adverse reactions of metformin gastrointestinal tract. In view of the small number of samples and the small number of samples, it is necessary to carry out more large samples, multi-center and strict design of high quality RCT to verify the system evaluation in the future.
【作者单位】： 中山大学附属第六医院妇科;
【分类号】：R711.75
[Abstract]:Objective to evaluate the efficacy and safety of berberine versus metformin in the treatment of polycystic ovary syndrome (PCOS). Methods the PUBMED,Cochrane database, China Zhiwang, Weip and Wanfang data platform were searched by computer. From the establishment of the database to February 2015, a randomized controlled trial (RCT).) with berberine versus metformin was used to treat PCOS. According to the evaluation method of Cochrane system, the statistical analysis was carried out with Rev Man 5.3 software. Results A total of 197 cases of PCOS were included in 3 RCT, patients, 98 cases in the trial group and 99 cases in the control group. The results of Meta analysis showed that berberine decreased waist-to-hip ratio, fasting insulin, and insulin, Total cholesterol and low density lipoprotein cholesterol levels were superior to metformin in lowering body mass index, fasting blood glucose, homeostasis model to evaluate insulin resistance index, triacylglycerol. The effects of total testosterone and elevated high density lipoprotein cholesterol were comparable to metformin. Conclusion compared with metformin, berberine is more suitable for the treatment of insulin resistance patients with central obesity and elevated fasting insulin level. Patients with hypercholesterolemia and high and low density lipoprotein cholesterol levels and PCOS patients who could not tolerate the adverse reactions of metformin gastrointestinal tract. In view of the small number of samples and the small number of samples, it is necessary to carry out more large samples, multi-center and strict design of high quality RCT to verify the system evaluation in the future.
【作者单位】： 中山大学附属第六医院妇科;
【分类号】：R711.75
【参考文献】
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