三伏贴联合西药治疗妊娠期支气管哮喘慢性持续期50例临床观察

发布时间：2018-10-29 16:57

【摘要】：目的观察三伏贴治疗妊娠期支气管哮喘(妊娠哮喘)慢性持续期患者的临床疗效及可能作用机制。方法将100例妊娠哮喘慢性持续期患者随机分为对照组和治疗组各50例。对照组给予布地奈德气雾剂吸入治疗,每次256μg,每天1次,共30天。治疗组在对照组的基础上给予三伏贴治疗,于头伏、二伏、三伏的第1天各治疗1次,末次贴敷10天后观察两组患者临床疗效、症状和体征缓解时间,检测两组患者治疗前后肺功能、血清降钙素(PCT)、25-羟维生素D3、血清C反应蛋白(CRP)水平及唾液中免疫球蛋白A(SIg A)、褪黑素和皮质醇水平。结果治疗后两组患者血清PCT、CRP水平较治疗前降低,25-羟维生素D3、SIg A、褪黑素和皮质醇水平提高,肺功能改善,差异均有统计学意义(P0.05)。治疗组治疗后血清PCT和CRP较对照组明显降低,25-羟维生素D3、SIg A、褪黑素和皮质醇水平、肺功能明显提高(P0.05)。治疗组喘息、咳嗽、肺部哮鸣音、胸膈满闷缓解时间明显短于对照组(P0.05)。治疗组临床疗效总有效率91.49%,对照组为75.00%,治疗组疗效优于对照组(P0.05)。结论三伏贴可能通过降低血清PCT、CRP水平,提高血清25-羟维生素D3和唾液中SIg A、褪黑素和皮质醇水平使妊娠哮喘慢性持续期患者临床症状得到有效控制。
[Abstract]:Objective to observe the clinical effect and possible mechanism of Sanfu plaster in the treatment of patients with pregnancy asthma. Methods 100 patients with chronic pregnancy asthma were randomly divided into two groups: control group (n = 50) and treatment group (n = 50). The control group was treated with budesonide aerosol inhalation, 256 渭 g, once a day for 30 days. The treatment group was treated with Sanfu paste on the basis of the control group, treated once on the first day of scalp, 2 volts and 3 volts, and 10 days after the last application, the clinical effects, symptoms and signs of the two groups were observed. Lung function, serum calcitonin (PCT), 25-hydroxyvitamin D3, serum C-reactive protein (CRP) and saliva immunoglobulin A (SIg A), melatonin and cortisol levels were measured before and after treatment. Results after treatment, the serum PCT,CRP level of the two groups was lower than that before treatment, the levels of 25-hydroxyvitamin D _ 3 sig _ A, melatonin and cortisol were increased, and the lung function was improved, there was significant difference between the two groups (P0.05). The levels of serum PCT and CRP in the treatment group were significantly lower than those in the control group. The levels of 25-hydroxyvitamin D _ (3) sig A, melatonin and cortisol, and pulmonary function were significantly increased (P0.05). The time of relief of wheezing, cough, lung wheezing and fullness of chest and diaphragm in the treatment group was significantly shorter than that in the control group (P0.05). The total effective rate of the treatment group was 91.49 and that of the control group was 75.00. The curative effect of the treatment group was better than that of the control group (P0.05). Conclusion Sanfu paste can effectively control the clinical symptoms of patients with chronic pregnancy asthma by lowering the level of serum PCT,CRP and increasing the levels of serum 25-hydroxyvitamin D _ 3, SIg A, melatonin and cortisol in saliva.
【作者单位】：河北联合大学中医学院;
【基金】：国家自然科学基金(81303046)
【分类号】：R714.253

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