超声引导下甲氨蝶呤局部注射联合米非司酮治疗未破裂型输卵管妊娠

发布时间：2018-10-31 07:09

【摘要】：目的探讨超声引导下甲氨蝶呤(methotrexate,MTX)局部注射联合米非司酮治疗未破裂型输卵管妊娠的疗效。方法 2013年1月~2014年2月对120例未破裂型输卵管妊娠,在B超引导下在未破裂型输卵管妊娠囊内注射MTX1 mg/kg,同时口服米非司酮75 mg,2次/d,共4 d。结果超声引导下112例1次穿刺成功,8例2次穿刺成功。80例(66.7%)治疗后第4天β-h CG下降15%,10例(8.3%)无明显变化,30例(25.0%)上升,但15%。105例治疗后第7天β-h CG下降15%,治疗后第14天进一步下降,1个月后降为阴性,腹痛明显缓解至消失,阴道流血停止,包块缩小或消失,治疗成功率87.5%(105/120)。住院费用1208.5~2722.6元,平均1859.4元。余15例腹腔镜手术治疗。结论超声引导下MTX局部注射联合米非司酮治疗未破裂型输卵管妊娠简便、安全。
[Abstract]:Objective to investigate the effect of local injection of methotrexate (methotrexate,MTX) combined with mifepristone on unruptured tubal pregnancy. Methods from January 2013 to February 2014, 120 cases of unruptured tubal pregnancy were treated with intrathecal injection of MTX1 mg/kg, and oral mifepristone 75 times per day for 4 days under the guidance of B-ultrasound. Results under the guidance of ultrasound, 112 cases were successfully punctured once, 8 cases 2 times successfully, 80 cases (66.7%) were successfully punctured, 10 cases (8.3%) of 尾 -h CG decreased in 15 cases (8.3%) on the 4th day after treatment, 30 cases (25.0%) increased. However, 尾 -h CG decreased by 15% on the 7th day after treatment, further decreased on the 14th day after treatment, decreased to negative one month later, abdominal pain obviously relieved to disappear, vaginal bleeding stopped, and mass decreased or disappeared. The success rate of treatment was 87.5% (105 / 120). The hospitalization expenses were 1208.5 yuan, 2722.6 yuan, with an average of 1859.4 yuan. The remaining 15 cases were treated by laparoscopic surgery. Conclusion Ultrasound-guided local injection of MTX combined with mifepristone in the treatment of unruptured tubal pregnancy is simple and safe.
【作者单位】：汉中市人民医院妇产科;
【分类号】：R714.22

【参考文献】