左炔诺孕酮宫内缓释系统与小剂量米非司酮在子宫腺肌病治疗中的疗效比较研究

发布时间：2018-11-02 15:04

【摘要】：目的探讨左炔诺孕酮宫内缓释系统与小剂量米非司酮在子宫腺肌病治疗中的治疗效果。方法选择2015年1月—2016年12月我院妇产科接受治疗的100例子宫腺肌病患者,随机分为左炔诺孕酮宫内缓释系统组和米非司酮组,每组50例,分别接受子宫放置左炔诺孕酮宫内缓释系统与口服小剂量米非司酮进行治疗。检查两组患者治疗前、后子宫体积、月经情况及骨密度,采用视觉模拟评分法(VAS)评估治疗前、后痛经疼痛情况,并观察两组患者临床疗效。结果治疗前和治疗后,两组月经量、月经周期、经期、VAS得分、骨密度及子宫体积分别比较,差异均无统计学意义(P0.05)。两组治疗后与治疗前比较,月经量减少,月经周期延长,经期缩短,VAS得分降低,子宫体积减小,差异有统计学意义(P0.05)。两组患者总有效率及不良反应发生率比较,差异均无统计学意义(P0.05)。结论左炔诺孕酮宫内缓释系统与小剂量米非司酮在子宫腺肌病治疗中均具有较为理想的治疗效果,可有效改善患者月经情况及痛经症状,子宫体积减小,疗效确切,安全性高。
[Abstract]:Objective to evaluate the efficacy of levonorgestrel in the treatment of adenomyosis. Methods from January 2015 to December 2016, 100 patients with adenomyosis were randomly divided into levonorgestrel intrauterine release system group and mifepristone group with 50 cases in each group. Intrauterine delivery of levonorgestrel and oral low-dose mifepristone were performed respectively. The volume of uterus, menstruation and bone mineral density were examined before and after treatment in both groups. Visual analogue score (VAS) was used to evaluate the dysmenorrhea pain before and after treatment, and to observe the clinical efficacy of the two groups. Results before and after treatment, there was no significant difference in menstrual volume, menstrual cycle, menstrual period, VAS score, bone mineral density and uterine volume between the two groups (P0.05). After treatment, compared with before treatment, menstrual volume decreased, menstrual cycle prolonged, menstrual period shortened, VAS score decreased, uterine volume decreased, the difference was statistically significant (P0.05). There was no significant difference in the total effective rate and the incidence of adverse reactions between the two groups (P0.05). Conclusion levonorgestrel intrauterine slow-release system and low-dose mifepristone are effective in the treatment of adenomyosis, which can effectively improve menstruation and dysmenorrhea symptoms, reduce uterine volume, and have high efficacy and safety.
【作者单位】：湖北省黄石市中心医院;
【分类号】：R711.71

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