血红素氧化酶-1与非肥胖女性多囊卵巢综合征的关联性研究

发布时间：2018-11-05 16:17

【摘要】：目的探讨循环中血红素氧化酶-1(HO-1)是否参与了多囊卵巢综合征(PCOS)的发生。方法获得知情同意后,按照年龄和体重指数(BMI)匹配的原则,检测了80名PCOS患者和80名健康对照者的临床特征、外周血中激素水平以及糖脂代谢情况,提取并量化血清中HO-1。分析HO-1与PCOS发病风险的关系,并界定其预测作用。结果PCOS组妇女较对照组存在显著增加的胰岛素抵抗(IR)、氧化应激(OS)和炎症状态,三者共同作用,对PCOS的病理生理过程形成一个恶性循环。复合模型的受试者工作特征曲线(ROC)分析显示,纳入或不纳入HO-1的曲线下面积分别为0.864(95%CI0.808~0.919)与0.953(95%CI0.923~0.982)(P=0.000 5)。结论血清HO-1可能参与了PCOS发生和发展过程,提示HO-1可作为识别女性发生PCOS的一个早期生物学标志物。
[Abstract]:Objective to investigate the role of heme oxygenase-1 (HO-1) in the pathogenesis of polycystic ovary syndrome (PCOS) (PCOS). Methods after obtaining informed consent, 80 patients with PCOS and 80 healthy controls were examined for their clinical characteristics, levels of hormones in peripheral blood and metabolism of glucose and lipid according to the principle of age and body mass index (BMI) matching. Extraction and quantification of HO-1. in Serum To analyze the relationship between HO-1 and the risk of PCOS, and define its predictive role. Results compared with the control group, the women in the PCOS group had significantly increased insulin resistance, (IR), oxidative stress, (OS) and inflammation, which combined to form a vicious circle on the pathophysiological process of PCOS. The (ROC) analysis of the operating characteristic curve of the subjects in the composite model showed that the areas under the curve with or without HO-1 were 0.864 (95%CI0.808~0.919) and 0.953 (95%CI0.923~0.982) (P0. 0005) respectively. Conclusion Serum HO-1 may be involved in the pathogenesis and development of PCOS, suggesting that HO-1 may be an early biomarker for the recognition of PCOS in women.
【作者单位】：武汉轻工大学生物与制药工程学院;华中科技大学同济医学院营养与食品卫生学系;
【基金】：国家十二五科研支撑项目资助(No.2012BAI02B02)
【分类号】：R711.75

【参考文献】