不孕症妇女自然周期过早内源性黄体生成素峰的发生与排卵障碍的相关性研究
发布时间：2018-11-06 12:44
【摘要】：目的探讨不孕症妇女自然周期卵泡发育过程中,过早内源性黄体生成素(LH)峰与排卵障碍的相关性,为不孕症妇女行自然周期的辅助生殖技术(ART)治疗提供依据。方法选择2010年1月—2012年1月衢州市妇幼保健院生殖中心不孕症门诊确诊的102例不孕症患者为研究对象,通过尿LH半定量检测试纸结合阴道超声,检测出102例不孕症妇女共244个自然周期的卵泡生长、内源性LH峰值及落峰时间、排卵情况,依据检测结果分为尿LH峰阳性组、尿LH峰阴性组及过早LH峰组,比较3组的排卵率、未破裂黄素化卵泡(LUF)发生率、周期妊娠率。结果尿LH峰阳性组138个,尿LH峰阴性组44个,过早LH峰组62个。244个自然周期总排卵率为77.0%(188个周期),LUF发生率为21.3%(52个周期),周期妊娠率为20.9%(51个周期妊娠)。尿LH峰阳性组、尿LH峰阴性组及过早LH峰组的排卵率分别为91.3%、63.6%、54.8%,LUF发生率分别为8.7%、31.8%、41.9%,周期妊娠率分别为29.0%、11.4%、9.7%;其中尿LH峰阳性组的排卵率、周期妊娠率均高于尿LH峰阴性组和过早LH峰组(P0.05),尿LH峰阳性组LUF发生率低于尿LH峰阴性组和过早LH峰组(P0.05),尿LH峰阴性组和过早LH峰组的排卵率、周期妊娠率、LUF发生率比较,差异均无统计学意义(P0.05)。结论自然周期卵泡发育过程中容易出现过早的内源性LH峰,是导致排卵障碍影响妊娠率的重要因素。临床实践中过早内源性LH峰的出现,可预测提早排卵及黄素化卵泡不破裂综合征(LUFS)的发生,可适时注射人绒毛膜促性腺激素,加强黄体支持,以降低LUFS的发生,提高临床妊娠率。
[Abstract]:Objective to investigate the correlation between premature endogenous luteinizing hormone (LH) peak and ovulation disorder in infertile women during natural cycle follicle development, and to provide evidence for (ART) therapy of natural cycle assisted reproduction in infertile women. Methods from January 2010 to January 2012, 102 infertile patients diagnosed in the reproductive center of Quzhou Maternal and Child Health Hospital were selected as the study objects. Urine LH semi-quantitative test paper combined with vaginal ultrasound was used. The follicle growth, endogenous LH peak value, peak time and ovulation were detected in 102 infertile women. According to the results, they were divided into three groups: urine LH peak positive group, urine LH peak negative group and premature LH peak group. The ovulation rates of the three groups were compared. The incidence of (LUF) and pregnancy rate of unruptured luteinized follicles. Results there were 138 positive LH peaks in urine, 44 negative LH peaks and 62 premature LH peaks. The total ovulation rate of 244 natural cycles was 77.0% (21.3%) for 188 cycles (52 cycles). The rate of periodic pregnancy was 20.9% (51 cycles). The ovulation rate of urine LH peak positive group, urine LH peak negative group and premature LH peak group were 91.3% and 63.6%, 54.8% respectively. 11. 4 and 9. 7; The ovulation rate and pregnancy rate of urine LH peak positive group were higher than those of urine LH peak negative group and premature LH peak group (P0.05). The incidence of LUF in urine LH peak positive group was lower than that in urine LH peak negative group and premature LH peak group (P0.05). There was no significant difference in ovulation rate, cycle pregnancy rate and LUF incidence between urine LH peak negative group and premature LH peak group (P0.05). Conclusion premature endogenous LH peak is easy to occur in the development of natural cycle follicles, which is an important factor that causes ovulation disorder to affect pregnancy rate. The appearance of premature endogenous LH peak in clinical practice can predict the occurrence of early ovulation and luteinized follicular unruptured syndrome (LUFS), and can inject human chorionic gonadotropin (HCG), strengthen luteal support, and reduce the incidence of LUFS. To increase the clinical pregnancy rate.
【作者单位】： 浙江省衢州市妇幼保健院生殖中心;
【基金】：衢州市科技局项目基金(20091092)
【分类号】：R714.8
[Abstract]:Objective to investigate the correlation between premature endogenous luteinizing hormone (LH) peak and ovulation disorder in infertile women during natural cycle follicle development, and to provide evidence for (ART) therapy of natural cycle assisted reproduction in infertile women. Methods from January 2010 to January 2012, 102 infertile patients diagnosed in the reproductive center of Quzhou Maternal and Child Health Hospital were selected as the study objects. Urine LH semi-quantitative test paper combined with vaginal ultrasound was used. The follicle growth, endogenous LH peak value, peak time and ovulation were detected in 102 infertile women. According to the results, they were divided into three groups: urine LH peak positive group, urine LH peak negative group and premature LH peak group. The ovulation rates of the three groups were compared. The incidence of (LUF) and pregnancy rate of unruptured luteinized follicles. Results there were 138 positive LH peaks in urine, 44 negative LH peaks and 62 premature LH peaks. The total ovulation rate of 244 natural cycles was 77.0% (21.3%) for 188 cycles (52 cycles). The rate of periodic pregnancy was 20.9% (51 cycles). The ovulation rate of urine LH peak positive group, urine LH peak negative group and premature LH peak group were 91.3% and 63.6%, 54.8% respectively. 11. 4 and 9. 7; The ovulation rate and pregnancy rate of urine LH peak positive group were higher than those of urine LH peak negative group and premature LH peak group (P0.05). The incidence of LUF in urine LH peak positive group was lower than that in urine LH peak negative group and premature LH peak group (P0.05). There was no significant difference in ovulation rate, cycle pregnancy rate and LUF incidence between urine LH peak negative group and premature LH peak group (P0.05). Conclusion premature endogenous LH peak is easy to occur in the development of natural cycle follicles, which is an important factor that causes ovulation disorder to affect pregnancy rate. The appearance of premature endogenous LH peak in clinical practice can predict the occurrence of early ovulation and luteinized follicular unruptured syndrome (LUFS), and can inject human chorionic gonadotropin (HCG), strengthen luteal support, and reduce the incidence of LUFS. To increase the clinical pregnancy rate.
【作者单位】： 浙江省衢州市妇幼保健院生殖中心;
【基金】：衢州市科技局项目基金(20091092)
【分类号】：R714.8
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相关期刊论文 前4条
1 梅佩红;;B型超声监测排卵在不孕症诊治中的应用价值[J];中国计划生育学杂志;2013年07期
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