当前位置:主页 > 医学论文 > 妇产科论文 >

长非编码RNA GAS5在卵巢癌患者中的低表达及其临床意义(英文)

发布时间:2018-11-07 09:26
【摘要】:【目的】探讨长链非编码RNA GAS5在卵巢癌中的表达水平及其临床意义。【方法】收集卵巢癌患者的瘤体组织标本,通过实时荧光定量PCR检测GAS5在卵巢癌组织中的表达水平。采用相关性分析,分析其表达水平与临床病理特征之间的关系、及其与疾病预后之间的关系。【结果】在卵巢癌瘤体组织中GAS5表达显著下降(P=0.0004);GAS5的表达与瘤体体积呈负相关(d5 cm vs.d5 cm,P0.000 1);GAS5的表达与肿瘤期别呈负相关(Ⅰ~Ⅱgrades vs.Ⅲ~Ⅳgrades,P=0.0086)。采用Kaplan-Meier分析表明,GAS5表达水平越低患者预后和生存越差。【结论】GAS5在卵巢癌中的表达情况与临床病理特征以及预后相关,可作为潜在的卵巢癌检测标记物。
[Abstract]:[objective] to investigate the expression of long chain noncoding RNA GAS5 in ovarian cancer and its clinical significance. [methods] the expression of GAS5 in ovarian cancer was detected by real-time fluorescence quantitative PCR. Correlation analysis was used to analyze the relationship between the expression level and clinicopathological features and the prognosis of ovarian cancer. [results] the expression of GAS5 was significantly decreased in ovarian cancer (P0. 0004). The expression of GAS5 was negatively correlated with tumor volume (d5 cm vs.d5 cm,P0.000 1) and GAS5 was negatively correlated with tumor stage (鈪,

本文编号:2315924

资料下载
论文发表

本文链接:https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2315924.html


Copyright(c)文论论文网All Rights Reserved | 网站地图 |

版权申明:资料由用户63941***提供,本站仅收录摘要或目录,作者需要删除请E-mail邮箱bigeng88@qq.com