卵巢上皮性肿瘤患者人乳头状瘤病毒感染及核转录因子表达与临床相关性研究

发布时间：2018-11-07 12:39

【摘要】：目的探讨人乳头状瘤病毒(HPV)感染和核转录因子(NF-кB)表达与卵巢上皮性肿瘤的关系,为临床治疗提供依据。方法选取2008年1月-2013年10月71例卵巢肿瘤患者的病理标本,检测卵巢上皮肿瘤组织HPV感染和NF-кB表达情况,分析与临床、病理的相关性。结果卵巢上皮癌患者HPV的阳性率要明显高于良性肿瘤患者,分别为36.73%、9.09%,差异有统计学意义(P0.05);卵巢上皮癌患者NF-кBp65的阳性率较良性肿瘤患者明显升高,分别为69.39%、17.17%,差异有统计学意义;HPV感染在卵巢癌不同临床病理结果比较,差异无统计学意义;卵巢上皮癌患者的临床分期、病理分级及CA125值在不同等级NF-кB阳性率的比较,差异有统计学意义(P0.05),病理分化程度越低、临床分期越晚及CA125值越高,NF-кB阳性率越高。结论 HPV感染和NF-кB的高表达与卵巢癌的发生有一定的关系,HPV感染患者应予积极治疗,以预防卵巢癌的发生。
[Abstract]:Objective to investigate the relationship between human papillomavirus (HPV) (HPV) infection and nuclear transcription factor B (NF- B) expression in ovarian epithelial tumors. Methods from January 2008 to October 2013, 71 cases of ovarian neoplasms were examined for HPV infection and NF- B expression, and the correlation with clinical and pathological features was analyzed. Results the positive rate of HPV in ovarian epithelial carcinoma was significantly higher than that in benign tumor (36.739.09, respectively), the difference was statistically significant (P0.05). The positive rate of NF- Bp65 in ovarian epithelial carcinoma patients was significantly higher than that in benign tumor patients (69.39 and 17.17, respectively), and there was no significant difference in HPV infection in different clinicopathological results of ovarian cancer. The difference of clinical stage, pathological grade and CA125 value in different grade of NF- positive rate was statistically significant (P0.05). The lower the degree of pathological differentiation, the later the clinical stage and the higher the CA125 value. The positive rate of NF- B was higher. Conclusion HPV infection and high expression of NF- B are related to the occurrence of ovarian cancer. Patients with HPV infection should be treated actively to prevent the occurrence of ovarian cancer.
【作者单位】：郑州人民医院妇科;复旦大学附属妇产科医院宫颈疾病诊治中心;郑州人民医院妇产科;
【基金】：河南省科技支撑基金资助项目(09276103D)
【分类号】：R737.31

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