早期血清β-hCG对卵裂期胚胎或囊胚移植后妊娠结局的预测

发布时间：2018-11-10 17:29

【摘要】：【目的】比较卵裂期胚胎及囊胚移植后早期血清β-人绒毛膜促性腺激素(β-h CG)对体外受精-胚胎移植(IVF-ET)妊娠结局的预测作用。【方法】回顾性分析自2010年6月至2015年5月共2 421个在本中心行IVF-ET后临床确认宫内单胎妊娠的患者周期的数据。比较分析卵裂期胚胎移植后14 d的血清β-h CG值及囊胚移植后12 d的血清β-h CG值与妊娠结局的关系。【结果】对于临床确认宫内妊娠的患者,囊胚移植组的早期β-h CG水平高于卵裂期胚胎移植组(687 U/L vs503 U/L)。根据妊娠结局分组后,这种差异同样存在于自然流产、继续妊娠(OP)及活产(LB)的患者中。根据新鲜或冷冻移植分组后,这种差异仅在冷冻移植组中有统计学意义。对于冷冻卵裂期胚胎移植的患者,以β-h CG475 U/L作为活产的预测值(灵敏度79.0%,特异度61.3%)。对于冷冻囊胚移植的患者,以β-h CG575 U/L作为活产的预测值(灵敏度74.9%,特异度59.2%)。【结论】冷冻移植周期中,囊胚移植的早期血清β-h CG值高于卵裂期胚胎。移植胚胎时期不同,应用早期血清β-h CG值预测妊娠结局的预测值也不同。囊胚或卵裂期胚胎移植后的早期血清β-h CG值均能有效预测活产结局。
[Abstract]:[objective] to compare the predictive effect of serum 尾-human chorionic gonadotropin (尾-h CG) on pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) between cleavage embryo and early stage of blastocyst transplantation. [methods] From June 2010 to May 2015, data of 2 421 patients with intrauterine single pregnancy confirmed by IVF-ET in our center were analyzed. The relationship between serum 尾 -h CG at 14 days after embryo transfer in cleavage stage and serum 尾 -h CG at 12 days after blastocyst transplantation was compared with pregnancy outcome. [results] for patients with clinically confirmed intrauterine pregnancy, The early 尾-h CG level in blastocyst transplantation group was higher than that in cleavage embryo transfer group (687 U / L vs503 U / L). After grouping according to pregnancy outcome, this difference also existed in patients with spontaneous abortion, continuing pregnancy with (OP) and live birth (LB). This difference was only statistically significant in the cryopreservation group according to the fresh or frozen group. For frozen cleavage embryo transfer patients, 尾 -h CG475 UP / L was used as the predictor of live delivery (sensitivity 79.0%, specificity 61.3%). For frozen blastocyst transplantation patients, 尾 -h CG575 U / L was used as the predictor of live birth (sensitivity 74.9%, specificity 59.2%). [conclusion] during the cryopreservation period, The serum 尾-h CG value of blastocyst transplantation was higher than that of cleavage embryo. Early serum 尾-h CG was used to predict pregnancy outcome in different embryo stage. The serum 尾-h CG values of blastocysts or cleavage embryos were effective in predicting the outcome of live delivery.
【作者单位】：中山大学附属第六医院生殖医学研究中心;南方医科大学南方医院妇产科生殖医学中心;
【基金】：广东省医学科学技术研究基金(A2015025)
【分类号】：R714.8

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