宫颈癌患者治疗前检测外周血细胞角蛋白19 mRNA和鳞状细胞癌抗原的临床意义

发布时间：2018-11-11 16:55

【摘要】：目的通过检测宫颈癌患者治疗前外周血中细胞角蛋白(CK)19 mRNA和鳞状细胞癌抗原(SCC-Ag)的表达,探讨其对宫颈癌的诊断意义及与临床病理的相关性。方法对100例宫颈癌患者行治疗前外周血CK19 mRNA及SCC-Ag检测,以40例健康妇女为对照,分析其作为诊断参考的特异性和敏感性,并对两者与宫颈癌临床病理特征的相关性进行分析。结果 CK19 mRNA、SCC-Ag检测诊断宫颈癌的特异性均为97.5%。CK19 mRNA、SCC-Ag水平升高用于治疗前诊断的敏感性分别为39%和57%,两者差异显著(P0.05)。CK19 mRNA表达升高与深肌层浸润(P=0.031)、盆腔淋巴结转移(P=0.027)相关。SCC-Ag水平升高与病理类型(P=0.005)、肿瘤大小(P=0.002)、深肌层浸润(P=0.001)、盆腔淋巴结转移(P=0.012)显著相关。结论外周血CK19 mRNA和SCC-Ag均是宫颈癌微转移有价值的肿瘤标志物;就宫颈鳞癌患者而言,SCC-Ag仍然是目前首选的肿瘤标志物。
[Abstract]:Objective to detect the expression of cytokeratin (CK) 19 mRNA and squamous cell carcinoma antigen (SCC-Ag) in peripheral blood of patients with cervical cancer before treatment, and to explore the diagnostic significance and clinicopathological significance of the expression of cytokeratin 19 mRNA and squamous cell carcinoma antigen (SCC-Ag). Methods Peripheral blood CK19 mRNA and SCC-Ag were detected in 100 patients with cervical cancer before treatment and 40 healthy women as control. The correlation between them and the clinicopathological features of cervical cancer was analyzed. Results the specificity of CK19 mRNA,SCC-Ag in the diagnosis of cervical cancer was 39% and 57%, respectively. There was significant difference between the two groups (P0.05). The increase of CK19 mRNA expression was associated with deep muscular invasion (P0.031), pelvic lymph node metastasis (P0. 027), and SCC-Ag level with pathological type (P0. 005) and tumor size (P0. 002). Deep muscular infiltration (P0. 001) and pelvic lymph node metastasis (P0. 012) were significantly correlated. Conclusion both CK19 mRNA and SCC-Ag in peripheral blood are valuable tumor markers for micrometastasis of cervical cancer and SCC-Ag is still the first choice for cervical squamous cell carcinoma.
【作者单位】：昆明医科大学第三附属医院(云南省肿瘤医院)妇瘤科;
【基金】：云南省应用基础研究项目(2013FB168)
【分类号】：R737.33

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