CD24和OPN在上皮性卵巢肿瘤的表达及其与侵袭转移的关系

发布时间：2018-11-15 15:59

【摘要】：目的探讨CD24和OPN在上皮性卵巢肿瘤发生发展中的表达,进一步了解卵巢癌的发病机制及CD24和OPN的高表达对卵巢癌侵袭转移的影响。方法应用免疫组织化学(SP)法,检测正常卵巢组织、良性上皮性卵巢肿瘤、交界性上皮性卵巢肿瘤、上皮性卵巢癌中CD24和OPN的表达。结果免疫组化结果显示,CD24蛋白的表达水平随着卵巢正常、良性、交界性和恶性性质的变化而逐步上升,各组间差异具有统计学意义(P0.05);随着临床分期升高而表达率升高,病理分级升高而表达率降低,表达无组织学特异性。OPN蛋白的表达水平随着正常、良性、交界性和恶性性质的变化而逐步上升,各组间差异具有统计学意义(P0.05);临床分期升高表达率升高,病理分级升高表达率降低,表达无组织学特异性。CD24和OPN表达阳性率间呈正相关(P0.05)。结论 CD24、OPN蛋白的高表达在卵巢肿瘤的发生、发展、侵袭转移中起重要作用;CD24和OPN的表达可以预测卵巢癌的发展、预后及复发风险。
[Abstract]:Objective to investigate the expression of CD24 and OPN in the carcinogenesis and development of epithelial ovarian tumors, and to further understand the pathogenesis of ovarian cancer and the effect of high expression of CD24 and OPN on the invasion and metastasis of ovarian cancer. Methods the expression of CD24 and OPN in normal ovarian tissue, benign epithelial ovarian tumor, borderline epithelial ovarian tumor and epithelial ovarian carcinoma were detected by immunohistochemical (SP) method. Results Immunohistochemical results showed that the expression of CD24 protein increased gradually with the changes of normal, benign, borderline and malignant nature of ovary, and the difference was statistically significant (P0.05). The expression of OPN protein increased with the change of normal, benign, borderline and malignant properties. The differences among groups were statistically significant (P0.05). The expression of CD24 and OPN were positively correlated (P0.05). Conclusion the overexpression of CD24,OPN protein plays an important role in the occurrence, development, invasion and metastasis of ovarian tumors, and the expression of CD24 and OPN can predict the development, prognosis and recurrence of ovarian cancer.
【作者单位】：西安交通大学医学部第二附属医院妇产科;西安市第四医院妇产科;西安未央正泰医院;西北工业大学医院;
【基金】：陕西省社会发展科技攻关项目(No.2015SF117)~~
【分类号】：R737.31

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