卵巢癌患者生存质量评估

发布时间：2018-11-16 10:45

【摘要】：目的：调查卵巢癌患者的生活状况，了解卵巢癌患者的症状群，分析影响患者生活质量的因素，为缓解卵巢癌患者症状、提高其生活质量提供参考。方法：采用随机抽样法，对2012年5月至2013年10月就诊于吉林省长春市2家三级甲等医院的卵巢癌患者94例（其中初发病者43例、复发患者51例）进行问卷调查，共获得有效问卷180份。采用社会人口学资料调查表、世界卫生组织生存质量测定量表(WHOQOL一100)和卵巢癌特异性问卷应用SPSS7.0对资料进行分析，对社会人口学资料调查表、症状和生活质量进行描述性分析；对生活质量的组间差异采用单因素方差分析；把生活质量作为因变量，将其相关因素作为自变量，进行多元逐步回归法分析卵巢癌患者生活质量的影响因素。结果： 1、卵巢癌患者得分较高的症状是乏力、呕吐、悲伤感、胃口差及脱发；这些症状对生理状况和感情状况的影响较大，对社会/家庭状况的影响较小。 2、卵巢癌患者术后及化疗期间常见的症状群有5个，包括：疼痛相关的症状群，心理症状群，围绝经期症状，胃肠道相关症状群，化疗副作用症状群。 3、卵巢癌患者生存质量的平均得分为94.58±4.25。各维度得分由低到高依次为生理状况、卵巢癌特异模块、功能状况、情感状况及社会/家庭状况。患者的年龄、家庭月收入、医保类型、体力状况、化疗时间点、有无复发及临床分期对患者的生存质量有显著的影响，而文化程度、居住地、职业、婚姻状况、病理类型及有无慢性疾病对患者的生存质量无统计学意义。 4、疼痛相关的症状群与生理状况及卵巢癌特异性模块相关；围绝经症状群与生理状况相关；心理症状群与情感状况及社会/家庭状况相关；胃肠道相关症状群与生理状况功能状况及卵巢癌特异性模块相关；化疗副作用症状群与生理状况、功能状况及卵巢癌特异性模块相关。结论： 1、卵巢癌患者术后及化疗期间常见的症状群有5个，包括：疼痛相关的症状群，心理症状群，，围绝经期症状，胃肠道相关症状群，化疗副作用症状群。 2、不同治疗阶段存在不同的症状群，且其强度及群内构成成分不同。 3、卵巢癌患者的生存质量受多种因素的影响，症状群与生存质量呈负相关，对其进行有效地干预可提高患者的生存质量。
[Abstract]:Objective: to investigate the living conditions of patients with ovarian cancer, to understand the symptom group of patients with ovarian cancer, and to analyze the factors affecting the quality of life of patients with ovarian cancer, so as to provide a reference for alleviating the symptoms of patients with ovarian cancer and improving their quality of life. Methods: from May 2012 to October 2013, 94 patients with ovarian cancer (43 patients with initial onset and 51 patients with recurrence) who were admitted to 2 Grade 3A hospitals in Changchun, Jilin Province, were investigated by random sampling. A total of 180 valid questionnaires were obtained. Social demographics questionnaire, World Health Organization quality of Life scale (WHOQOL -100) and Ovarian Cancer specificity questionnaire were used to analyze the data. Descriptive analysis of symptoms and quality of life; Univariate ANOVA was used to analyze the difference of quality of life among groups, and quality of life was regarded as dependent variable and related factors were taken as independent variables to analyze the influencing factors of quality of life of ovarian cancer patients by multivariate stepwise regression method. Results: 1 the symptoms with higher scores of ovarian cancer were fatigue, vomiting, sadness, poor appetite and alopecia. 2. There are 5 common symptom groups in patients with ovarian cancer after operation and during chemotherapy, including: pain related symptom group, psychological symptom group, peri-menopausal symptom group, gastrointestinal tract related symptom group, chemotherapy side effect symptom group. The mean quality of life score of ovarian cancer patients was 94.58 卤4.25. The scores of each dimension from low to high were physiological status, ovarian cancer specific module, functional status, emotional status and social / family status. Age, monthly income of family, type of medical insurance, physical condition, time point of chemotherapy, recurrence and clinical stage had significant effects on patients' quality of life, while education, residence, occupation, marital status, There was no significant difference in quality of life (QOL) between pathological types and chronic diseases. (4) pain related symptom group was related to physiological status and ovarian cancer specific module, perimenopausal symptom group was related to physiological condition, psychological symptom group was related to emotional state and social / family condition. Gastrointestinal related symptom group was related to physiological status and ovarian cancer specific module, and chemotherapy side effect symptom group was related to physiological status, function status and ovarian cancer specificity module. Conclusion: 1. There are 5 common symptom groups in patients with ovarian cancer after operation and during chemotherapy, including: pain related symptom group, psychological symptom group, peri-menopausal symptom group, gastrointestinal tract related symptom group, chemotherapy side effect symptom group. 2. There are different symptom groups in different treatment stages, and their strength and composition are different. 3. The quality of life of ovarian cancer patients was affected by many factors, and the symptom group was negatively correlated with the quality of life. Effective intervention could improve the quality of life.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.31

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