小剂量多巴胺与羟乙基淀粉溶液联合治疗重度卵巢过度刺激综合征的临床观察

发布时间：2018-11-17 08:42

【摘要】：目的:探讨小剂量多巴胺与羟乙基淀粉溶液联合治疗重度卵巢过度刺激综合征的临床疗效。方法:选择重度卵巢过度刺激综合征(OHSS)患者60例,使用随机数字法分为两组,对照组30例采用羟乙基淀粉溶液500~1000 ml/d,静脉滴注10~14天,同时采用白蛋白加胸腹腔积液抽吸治疗;治疗组30例在对照组治疗方法的基础上同时加用小剂量多巴胺40 mg/d(2μg/kg·min),静脉滴注,用药7~10天。观察并比较两组患者血生化相关指标及住院时间、住院费用等的差异。结果:治疗组总蛋白、白蛋白的疗效优于对照组,差异有统计学意义(P0.01)。治疗组尿量恢复时间、血细胞比容恢复时间、住院时间明显比对照组短,差异有统计学意义(P0.01,P0.05)。治疗组住院费用明显比对照组低,差异有统计学意义(P0.01)。两组治疗后均能有效改善OHSS症状、体征和血液生化指标。白细胞、尿素氮、肌酐、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、钾、钠治疗前后比较,差异无统计学意义(P0.05)。结论:重度OHSS患者应用小剂量多巴胺与羟乙基淀粉溶液联合治疗,能迅速缓解症状,缩短住院时间,降低住院费用及减少并发症的发生,为治疗OHSS的一种有效方法。
[Abstract]:Objective: to investigate the clinical effect of low dose dopamine and hydroxyethyl starch solution in the treatment of severe ovarian hyperstimulation syndrome. Methods: sixty patients with severe ovarian hyperstimulation syndrome (OHSS) were randomly divided into two groups. 30 patients in the control group were treated with hydroxyethyl starch solution of 500-1000 ml/d, intravenously for 10 ~ 14 days. At the same time, the patients were treated with albumin plus aspiration of pleural and peritoneal effusion. 30 patients in the treatment group were treated with small dose dopamine 40 mg/d (2 渭 g/kg min),) for 10 days on the basis of the control group. To observe and compare the difference of blood biochemical indexes, hospitalization time and hospitalization cost between the two groups. Results: the therapeutic effect of total protein and albumin in the treatment group was better than that in the control group (P 0.01). The recovery time of urine volume blood cell volume and hospitalization time in the treatment group were significantly shorter than those in the control group (P 0.05). The cost of hospitalization in the treatment group was significantly lower than that in the control group (P 0.01). Both groups were able to improve the symptoms, signs and blood biochemical indexes of OHSS after treatment. WBC, urea nitrogen, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), potassium, sodium before and after treatment, there was no significant difference (P0.05). Conclusion: the combination therapy of low dose dopamine and hydroxyethyl starch solution in patients with severe OHSS can quickly relieve symptoms, shorten hospitalization time, reduce hospitalization cost and reduce complications. It is an effective method for the treatment of OHSS.
【作者单位】：四川省医学科学院·四川省人民医院;
【分类号】：R711.75

【参考文献】