甘肃地区女性宫颈HPV感染的现状研究

发布时间：2018-11-17 18:10

【摘要】：目的:了解甘肃地区女性人乳头瘤病毒(HPV)感染的基因亚型、年龄及地区分布等.方法:采用凯普医用核酸分子快速导流杂交基因芯片技术,对7318名兰州女性进行生殖道21种HPV感染基因亚型筛查.结果:甘肃地区女性HPV感染率为19.9%(1 452/7 318),其中高危型HPV感染率14.78%(1 082/7 318),低危型HPV感染率3.38%(247/7 318),高危型中HPV16为主要致病亚型,占28.59%(415/1 452),低危型中HPV6占6.30%(98/1 452).1452例感染HPV的标本中,单一感染1 188例,占81.82%(1 188/1 452),多重感染264例,占18.18%(264/1 452).按年龄分组中≥50岁组HPV感染率最高,占24.24%.按地区分析,陇南地区HPV感染率最高,达到30.97%(83/268).结论:甘肃地区为宫颈癌高发区,其中HPV16是感染最多的型别,对该地区女性进行子宫颈癌的筛查和防治已成为当务之急.
[Abstract]:Objective: to investigate the gene subtypes, age and regional distribution of female human papillomavirus (HPV) infection in Gansu. Methods: 7318 women in Lanzhou were screened for 21 HPV infection gene subtypes in the reproductive tract by using the gene chip technique of Kepper medical nucleic acid molecular fast diversion hybridization. Results: the infection rate of female HPV was 19. 9% (1 452 / 7 318). The infection rate of high risk type HPV was 14. 78% (10 82 / 7 318), and the infection rate of low risk type HPV was 3. 38% (247 / 7 318). HPV16 was the main pathogenic subtype of high risk type, accounting for 28.59% (415 / 1 452), HPV6 accounted for 6.30% (98 / 1 452) in low risk type. Among 1452 samples infected with HPV, 1 188 cases (81.82%) were single infection. 264 cases (18.18%) were multiple infections (264 / 1 452). The infection rate of HPV was the highest in the group of 鈮，

本文编号：2338655