FORT预测高龄不孕妇女IVF-ET结局的相关研究
发布时间：2018-11-18 07:23
【摘要】：目的:研究探讨卵泡输出率(Follicular out-put rate,FORT)在预测和指导行体外授精-胚胎移植(In vitro fertilization and embryo transfer,IVF-ET)技术的高龄不怀孕妇女助孕结局中的应用价值。方法:回顾性分析了2015年1月到2016年1月在新疆省乌鲁木齐市的新疆医科大学第一附属医院妇科生殖助孕中心就诊,应用了拮抗剂方案行控制性超排卵(Controlled ovarian hyperstimulation,COH)的高龄不孕妇女一共有130人的相关资料。根据计算所得FORT值的25%和75%中位数将所有符合纳入要求的目标人群分为高(n=33人)、中(n=41人)、低FORT(n=56人)组,比较三组人群间的COH结果及实验的一些相关指标。结果:三组病人在年龄大小、基础的的激素水平基础促卵泡激素(bFSH)、基础促黄体激素(bLH)、促性腺激素(Gn)使用的剂量及月经周期第三天直径大小为3-8mm的卵泡总个数(Antral follicle count,AFC)等基线的周期资料上没有统计学差异(P0.05)。比较三组人群间的排卵前卵泡数(Premature follicle count,PFC)、获卵数、2PN、2PN卵裂数、可移植胚胎数、优胚数,高、中FORT组均较低FORT组高,差异方面有统计学意义(P0.05),然而相关数据却在高FORT组与中FORT组间比较没有统计学上的意义(P0.05);就种植率和临床妊娠率这两个指标比较,三组间没有统计学差异(P0.05)。结论:FORT这一指标可以为高龄但不孕的妇女的临床助孕结局提供一定的临床指导:高FORT者在促排过成中卵巢对Gn的疗效会更好,但是FORT最终是否可以为高龄不孕妇女的助孕结局提供准确的预测价值尚需进一步探讨研究。
[Abstract]:Objective: to investigate the value of follicular output (Follicular out-put rate,FORT) in predicting and guiding the outcome of pregnancy assistance in elderly non-pregnant women using in vitro insemination and embryo transfer (In vitro fertilization and embryo transfer,IVF-ET) technique. Methods: from January 2015 to January 2016, a retrospective analysis was made at the Gynecological Center for Reproductive Assistance in the first affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province. The controlled hyperovulation (Controlled ovarian hyperstimulation,) was performed with antagonist regimen. COH) has a total of 130 elderly infertile women. According to the median of 25% and 75% of the calculated FORT, all the target groups that meet the inclusion requirements were divided into three groups: high (n = 33), middle (n = 41) and low FORT (n = 56). The results of COH and some related indexes of the experiment were compared among the three groups. Results: three groups of patients in age, size, basic hormone levels, basic follicle stimulating hormone (bFSH), basic luteinizing hormone (bLH),) There was no significant difference in the baseline data between the dosage of gonadotropin (Gn) and the total number of follicles with diameter of 3-8mm on the third day of menstrual cycle (P0.05). The number of pre-ovulation follicles (Premature follicle count,PFC), the number of eggs obtained, the number of cleavage of 2PNN 2PN, the number of transferable embryos, the number of superior embryos, the number of embryos in middle FORT group were higher than those in low FORT group (P0.05). However, there was no statistical significance between the high FORT group and the middle FORT group (P0.05). There was no statistical difference between the three groups on implant rate and clinical pregnancy rate (P0.05). Conclusion: the index of FORT can provide some clinical guidance for the outcome of assisted pregnancy in the elderly but infertile women. The effect of ovarian on Gn in patients with high FORT is better than that in the patients with high FORT. However, whether FORT can provide accurate predictive value for the outcome of assisted pregnancy in elderly infertile women needs further study.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.8
[Abstract]:Objective: to investigate the value of follicular output (Follicular out-put rate,FORT) in predicting and guiding the outcome of pregnancy assistance in elderly non-pregnant women using in vitro insemination and embryo transfer (In vitro fertilization and embryo transfer,IVF-ET) technique. Methods: from January 2015 to January 2016, a retrospective analysis was made at the Gynecological Center for Reproductive Assistance in the first affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province. The controlled hyperovulation (Controlled ovarian hyperstimulation,) was performed with antagonist regimen. COH) has a total of 130 elderly infertile women. According to the median of 25% and 75% of the calculated FORT, all the target groups that meet the inclusion requirements were divided into three groups: high (n = 33), middle (n = 41) and low FORT (n = 56). The results of COH and some related indexes of the experiment were compared among the three groups. Results: three groups of patients in age, size, basic hormone levels, basic follicle stimulating hormone (bFSH), basic luteinizing hormone (bLH),) There was no significant difference in the baseline data between the dosage of gonadotropin (Gn) and the total number of follicles with diameter of 3-8mm on the third day of menstrual cycle (P0.05). The number of pre-ovulation follicles (Premature follicle count,PFC), the number of eggs obtained, the number of cleavage of 2PNN 2PN, the number of transferable embryos, the number of superior embryos, the number of embryos in middle FORT group were higher than those in low FORT group (P0.05). However, there was no statistical significance between the high FORT group and the middle FORT group (P0.05). There was no statistical difference between the three groups on implant rate and clinical pregnancy rate (P0.05). Conclusion: the index of FORT can provide some clinical guidance for the outcome of assisted pregnancy in the elderly but infertile women. The effect of ovarian on Gn in patients with high FORT is better than that in the patients with high FORT. However, whether FORT can provide accurate predictive value for the outcome of assisted pregnancy in elderly infertile women needs further study.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.8
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