145例孕妇糖耐量状态与胰岛素抵抗和胰岛β细胞功能的关系研究

发布时间：2018-11-18 14:02

【摘要】：目的研究探讨孕妇不同糖耐量状态下胰岛素抵抗和胰岛β细胞功能的关系。方法 2014年10月至2016年10月在南京医科大学附属淮安市第一人民医院检查待产的妇女144例,根据糖耐量的试验结果分为妊娠期糖尿病(GDM)(A组共48例)、妊娠糖耐量减低(B组共48例)、结果正常(C组共48例),比较各组胰岛素抵抗和分泌功能及妊娠结果。结果 A、B、C三组HOMA-IR依次递减,A、B、C组之间差异有统计学意义(P0.05);HOMA-β依次增加,A组与B、C组之间差异有统计学意义(P0.05)。A、B、C三组AIR3-10、AUC-I依次升高,组间分别比较,差异有统计学意义(P0.05);三组AUC-Ⅱ也依次升高,A组与B、C组之间差异有统计学意义(P0.05);三组妊娠结果差异无统计学意义(P0.05)。结论与正常糖耐量孕妇相比,有妊娠糖尿病以及糖耐量减低孕妇不仅存在胰岛素抵抗,还有β细胞功能受损,且GDM孕妇胰岛素抵抗和β细胞功能受损情况更加严重。
[Abstract]:Objective to investigate the relationship between insulin resistance and islet 尾-cell function in pregnant women with different glucose tolerance. Methods from October 2014 to October 2016, 144 women were examined in Huaian first people's Hospital of Nanjing Medical University. According to the results of glucose tolerance test, they were divided into gestational diabetes mellitus (GDM) (A) group (48 cases). Impaired glucose tolerance (group B, n = 48) and normal results (group C, n = 48). Insulin resistance and secretory function and pregnancy outcome were compared in each group. Results the HOMA-IR of the three groups decreased in turn, and the difference between the three groups was statistically significant (P0.05). HOMA- 尾 increased in turn, the difference between group A and group C was statistically significant (P0.05). The AIR3-10,AUC-I of group A and group C increased in turn, and the difference was statistically significant (P0.05). AUC- 鈪，

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