短时授精对IVF受精正常患者治疗结局的影响

发布时间：2018-11-18 20:11

【摘要】：目的:探讨短时授精对IVF受精正常患者体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法:回顾性分析IVF受精率60%患者的临床资料,按授精方案分为短时授精组(n=153)和常规受精组(n=180)。结果:IVF短时授精组和常规IVF组分别获卵1 619枚和1 986枚,分别有133名和152名患者接受了新鲜胚胎移植。组间女方年龄、基础FSH(b FSH)、b LH、b E2、Gn量、h CG注射日FSH水平、h CG注射日E2水平、h CG注射日LH水平、获卵数、卵子成熟度及移植日内膜厚度均无统计学差异。IVF短时授精组和常规IVF组的正常受精率(65.55%vs 67.84%)、正常卵裂率(98.02%vs 96.90%)、胚胎种植率(29.41%vs 27.84%)、临床妊娠率(44.36%vs 45.39%)、继续妊娠率(41.35%vs 42.76%)、流产率(5.45%vs 2.90%)和异位妊娠率(1.82%vs 2.90%)均无统计学差异,但是短时授精组的多原核受精率(14.56%)显著高于常规IVF组(6.19%),而短时授精组的优质胚胎率(33.51%)高于常规IVF组(28.99%)。结论:因IVF短时授精可避免常规IVF完全受精失败而逐渐在国内广泛应用,但其远期影响还有待进一步认识。
[Abstract]:Aim: to investigate the effect of short-time insemination on the outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with normal IVF fertilization. Methods: the clinical data of 60% patients with IVF fertilization rate were retrospectively analyzed. According to the insemination scheme, they were divided into short-time insemination group (nong153) and conventional fertilization group (nt180). Results: 1 619 eggs and 1 986 eggs were obtained in IVF short time insemination group and routine IVF group, and 133 and 152 patients received fresh embryo transfer, respectively. Age of intergroup, basal FSH (b FSH), b LH,b E2Gn dose, FSH level on, h CG injection day, E2 level on, h CG injection day, LH level on, h CG injection day, number of eggs obtained, The normal fertilization rate (65.55%vs 67.84%) and normal cleavage rate (98.02%vs 96.90%) in IVF short-term insemination group and routine IVF group were not significantly different. Embryo implantation rate (29.41%vs 27.84%), clinical pregnancy rate (44.36%vs 45.39%), continuing pregnancy rate (41.35%vs 42.76%), There was no significant difference in abortion rate (5.45%vs 2.90%) and ectopic pregnancy rate (1.82%vs 2.90%), but the rate of multicore fertilization in short-term insemination group (14.56%) was significantly higher than that in conventional IVF group (6.19%). The rate of high quality embryos in short term insemination group (33.51%) was higher than that in conventional IVF group (28.99%). Conclusion: IVF short term insemination can avoid the failure of complete fertilization of conventional IVF, and it is widely used in China, but its long-term effects need to be further understood.
【作者单位】：北京大学深圳医院生殖医学科;
【基金】：国家自然科学基金项目(项目批准号:30900817) 深圳市科技计划项目(项目批准号:201302069,JCYJ201206 18,ZYC201006180435A)
【分类号】：R714.8

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