山东地区女性人乳头瘤病毒感染亚型、多重感染情况及年龄分布差异

发布时间：2018-11-19 12:08

【摘要】：目的了解山东地区女性人乳头瘤病毒(human papillomavirus,HPV)感染状况以及23种亚型分布特征、多重感染情况、在不同年龄组的分布差异。方法利用反向点杂交技术,对2013年1月至2014年11月山东省内13 973份门诊女性宫颈脱落细胞样本进行HPV分型检测,分析HPV感染亚型、多重感染情况及年龄分布差异。结果13 973份样本中,共检测出阳性样本4 105份,总检出率29.38%,23种亚型型别均有感染。单一型别感染2 513份,占阳性样本的61.25%,其中高危型感染1 815份,占阳性样本的44.21%,低危型感染698份,占阳性样本的17.00%;高危型感染最常见型别依次为16、52、58、56、53、66、18、68,低危型感染最常见型别依次为6、11、81、43、42。多重感染为1 592份,占阳性样本的38.75%,高低危混合感染占55.84%,纯高危型感染占39.20%;随着合并感染的型别数增加,比例逐渐下降。小于30岁人群有较高感染率,之后随年龄增长感染率呈下降趋势,而大于50岁年龄组,感染率又有所增加。结论山东地区女性HPV感染以单重感染为主,且高危型感染占优势;高危型感染以16型为主,低危型感染以6型为主。
[Abstract]:Objective to investigate the distribution of female human papillomavirus (human papillomavirus,HPV) infection and 23 subtypes in Shandong province. Methods from January 2013 to November 2014, 13 973 samples of cervical exfoliated cells from outpatients in Shandong province were detected by reverse dot hybridization for HPV typing. The subtypes of HPV infection, multiple infections and age distribution were analyzed. Results out of 13 973 samples, 4 105 positive samples were detected, the total detection rate was 29.3838% and 23 subtypes were all infected. There were 2 513 single type infections, accounting for 61.25% of positive samples, including 1 815 high risk type infections, accounting for 44.21% of positive samples, and 698 cases of low risk type infections, accounting for 17.00% of positive samples. The most common type of high risk type infection was 1652A58A56A53C661868, and the most common type of low-risk infection was 61181m43V42. There were 1 592 multiple infections, which accounted for 38.75% of the positive samples, 55.84% of high and low risk mixed infections, 39.20% of pure high-risk infections, and the proportion gradually decreased with the increase of the types of co-infection. The infection rate of the population under 30 years of age was higher, then the infection rate decreased with the increase of age, but the infection rate increased with the increase of the age group more than 50 years old. Conclusion female HPV infection in Shandong province is dominated by single infection, and high risk type infection is dominant, high risk type infection is mainly type 16 and low risk type infection is mainly type 6.
【作者单位】：济南金域医学检验中心实验室;天津金域医学检验所;
【分类号】：R737.33

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