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卵巢子宫内膜异位症181例临床分析

发布时间:2018-11-19 20:34
【摘要】:目的:探讨卵巢子宫内膜异位症复发的影响因素 方法:回顾性分析2009年1月-2012年12月经大连医科大学附属第一医院手术治疗的181例卵巢子宫内膜异位症患者临床资料,采用logistic回归分析影响术后复发的因素。 结果:(1)181例患者的平均年龄为34.7±1.8岁,,76.8%的患者年龄分布于21-40岁。 (2)181例患者中,113例(62.4%)月经改变,90例(49.7%)痛经,78例(43.1%)慢性盆腔痛,81例(44.8%)例不孕,表现性交痛有3例(1.7%)。181例病例常见临床表现依次为月经改变、痛经、不孕、慢性盆腔痛、性交痛。临床症状与临床分期相关,表现为临床分期越大,临床症状越复杂。 (3)Ⅰ期患者CA125阳性2例(25%),Ⅱ期患者CA125阳性3例(21.4%),Ⅲ期患者CA125阳性51例(61.4%),Ⅳ期患者CA125阳性55例(73.3%),CA125阳性率与临床分期相关,临床分期越晚,CA125值阳性率越高。 (4)应用logistic逐步回归分析卵巢子宫内膜异位症复发的相关因素,年龄、CA125值、AFS分期、手术方式均不是影响复发的因素;术后是否用药可以影响复发。 (5)181例患者术后给予辅助药物治疗102例,复发14例,术后未给予辅助药物治疗79例,复发23例,对两组患者的复发率差异进行X2检验,有统计学意义,表明术后未用药组复发率高于用药组。 (6)分析术后应用促性腺激素释放激素激动剂(GnRH-a)、避孕药、中药对复发率的影响,术后应用GnRH-a治疗76例,复发8例;口服避孕药治疗19例,复发6例;口服中药治疗7例,复发0例。对GnRH-a治疗组与口服避孕药组、GnRH-a治疗组与口服中药组、口服避孕药组与口服中药组复发率差异进行X2检验,结果为,GnRH-a治疗组与口服中药组、口服避孕药组与口服中药组治疗效果无差异,术后应用GnRH-a治疗优于口服避孕药。 结论:(1)卵巢子宫内膜异位症多分布于21-40岁育龄期妇女。 (2)患者的临床分期愈高,其临床表现越复杂,CA125水平阳性愈高。 (3)术后辅助用药可以减少术后复发,GnRH-a治疗效果优于避孕药。
[Abstract]:Objective: to investigate the factors influencing the recurrence of ovarian endometriosis. Methods: the clinical data of 181 patients with ovarian endometriosis treated by surgery from January 2009 to December 2012 in the first affiliated Hospital of Dalian Medical University were analyzed retrospectively. Logistic regression analysis was used to analyze the risk factors of postoperative recurrence. Results: (1) the average age of 181 patients was 34.7 卤1.8 years old, and 76.8% of the patients were aged 21-40 years. (2) among 181 patients, 113 (62.4%) had menorrhagia, 90 (49.7%) had dysmenorrhea, 78 (43.1%) had chronic pelvic pain, 81 (44.8%) had infertility. The common clinical manifestations of 181 cases were menstrual change, dysmenorrhea, infertility, chronic pelvic pain and intercourse pain. Clinical symptoms are related to clinical staging, the larger the clinical stage, the more complicated the clinical symptoms. (3) CA125 was positive in 2 cases (25%), CA125 in 3 cases (21.4%) in stage 鈪

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