无症状性BV的自然转归及其高危因素分析

发布时间：2018-11-20 21:07

【摘要】：目的:研究无症状性细菌性阴道病(BV)患者的自然转归情况,分析可能影响自然转归的高危因素。方法:从体检中心选取未治疗的无症状性BV患者160例,跟踪观察4个月,记录每例患者的病例特点及最终结局。单变量分析及多变量分析各种因素与结局之间的相关性。结果:160例患者中,41%病情进展,53%病情无明显变化,6%病情自行好转。病情进展的患者中,38%变为有症状的BV,24%变为BV合并VVC。单变量分析发现,经常出差(OR 3.72,95%CI 1.85~7.46)、BV病史(OR 4.78,95%CI 2.42~9.44)与患者病情进展有关。安全套避孕(OR=0.46,95%CI 0.24~0.90)、Nugent评分较低(OR=0.40,95%CI 0.21~0.79)对无症状BV有保护作用。多变量分析发现,安全套避孕对患者有保护作用,BV病史和经常出差是病情进展的高危因素。结论:对无症状性BV患者进行干预是必要的。
[Abstract]:Objective: to study the natural outcome of patients with asymptomatic bacterial vaginosis (BV) and analyze the risk factors that may influence the natural outcome. Methods: 160 untreated asymptomatic BV patients were selected from the physical examination center and followed up for 4 months. The characteristics and final outcome of each patient were recorded. Univariate analysis and multivariate analysis of the correlation between factors and outcomes. Results: among 160 patients, 41% were progressive, 53% had no obvious change, and 6% had self-improvement. 38% of patients with progressive disease became symptomatic BV,24% to BV with VVC. Univariate analysis showed that frequent travel (OR 3.7295 CI 1.857.46), BV history (OR 4.7895 CI 2.429.44) was associated with the patient's progression. Condom contraception (OR=0.46,95%CI 0.24 卤0.90), Nugent) had a protective effect on asymptomatic BV (OR=0.40,95%CI 0.210.79). Multivariate analysis showed that condom had protective effect on patients, BV history and frequent travel were high risk factors of disease progression. Conclusion: it is necessary to intervene in asymptomatic BV patients.
【作者单位】：北京大学第一医院;天津医科大学总医院;清华长庚医院;
【基金】：国家自然科学基金资助项目(No:81170535;No:81471420)
【分类号】：R711.31

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