3种方案治疗合并胰岛素抵抗的多囊卵巢综合症患者疗效研究

发布时间：2018-11-21 12:48

【摘要】：目的利用随机对照试验(RCT)评估PCOS患者行为治疗(锻炼及饮食控制)、二甲双肌与胰岛素增敏剂(罗格列酮)治疗的疗效,并进行疗效比较。总结3种胰岛素增敏治疗在临床的应用效果。方法将PCOS患者随机分为行为治疗、二甲双肌与罗格列酮3组,总结各组的治疗前后患者的人体学、生化、内分泌激素水平、治疗效果等观察指标并进行比较。结果 3组在治疗后的人体学、生化、激素指标无统计学差异,3组的疗效无明显差异。对3组排卵、月经情况比较,发现罗格列酮组优于行为治疗组。结论 PCOS是涉及多系统的疾病,要重视PCOS患者代谢综合征的筛查与诊治。二甲双胍,罗格列酮等胰岛素增敏治疗只造用于部分合并IR的PCOS患者,不能滥用。对PCOS患者实行个体化治疗,胰岛素增敏联合其它药物的应用,有望取得全面的治疗效果
[Abstract]:Objective to evaluate the efficacy of behavioral therapy (exercise and diet control), dimethylene dimuscle and insulin sensitizer (rosiglitazone) in patients with PCOS by randomized controlled trial (RCT). To summarize the clinical effect of three kinds of insulin sensitizing therapy. Methods the patients with PCOS were randomly divided into three groups: behavioral therapy, dimethylissimus group and rosiglitazone group. The observation indexes of human body, biochemistry, endocrine hormone and therapeutic effect were summarized and compared before and after treatment. Results there was no significant difference in ergonomics, biochemistry and hormone index in the three groups after treatment, and there was no significant difference in the curative effect among the three groups. The comparison of ovulation and menstruation in three groups showed that rosiglitazone group was superior to behavioral therapy group. Conclusion PCOS is a multi-system disease. Attention should be paid to the screening, diagnosis and treatment of metabolic syndrome in patients with PCOS. Metformin, rosiglitazone and other insulin sensitizing therapy are only used in PCOS patients with IR, and can not be abused. The application of individualized therapy and insulin sensitization combined with other drugs in patients with PCOS is expected to achieve a comprehensive therapeutic effect.
【作者单位】：郑州市妇幼保健院;
【分类号】：R711.75

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