子宫肌瘤和卵巢囊肿与血清中PAEs暴露水平关系

发布时间：2018-11-22 09:57

【摘要】：目的了解育龄女性血清酞酸酯类化学物(PAEs)的暴露水平,分析PAEs与子宫肌瘤、卵巢囊肿的相关性。方法在上海市第一妇婴保健院收集80例子宫肌瘤、67例卵巢囊肿和17例原发性不孕共164例妇科疾病患者和80例健康对照组血清,采用气相色谱法(GC)检测其血清中PAEs的含量,并分析其与妇科疾病的相关性。结果 244例女性中血清的邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二(2-乙基-己基)酯(DEHP)检出率分别为26.2%、95.5%和92.2%,几何均数分别为0.071、0.270和0.193 mg/L;病例组血清中DBP水平(0.342 mg/L)明显高于对照组(0.165 mg/L),差异有统计学意义(t=11.870,P0.01);子宫肌瘤组血清DBP含量与年龄因素呈负相关(r=-0.267,P=0.028),对照组血清中DBP含量与BMI值间存在正相关(r=0.270,P=0.017)。结论子宫肌瘤和卵巢囊肿与血清PAEs水平存在一定的相关性。
[Abstract]:Objective to investigate the exposure of serum phthalate esters (PAEs) to uterine leiomyomas and ovarian cysts in women of childbearing age and to analyze the correlation between PAEs and uterine leiomyoma and ovarian cysts. Methods 80 cases of uterine fibroids, 67 cases of ovarian cysts, 17 cases of primary infertility, 164 cases of gynecological diseases and 80 cases of healthy controls were collected from Shanghai first Women and infants Health Care Hospital. The serum PAEs levels were detected by gas chromatography (GC). The relationship between the disease and gynecological diseases was analyzed. Results the positive rates of dibutyl phthalate (DBP) and diethyl phthalate (2-ethyl-hexyl) phthalate (DEHP) were 26.295% and 92.2%, respectively. The geometric mean is 0.071 0.270 and 0.193 mg/L;, respectively. The serum DBP level in the case group (0.342 mg/L) was significantly higher than that in the control group (0.165 mg/L), and the difference was statistically significant (t = 11.870 / P0.01). There was a negative correlation between serum DBP content and age factors in uterine leiomyoma group (r = -0.267), and a positive correlation between serum DBP content and BMI value in control group (r = 0.270, P < 0.017). Conclusion there is some correlation between uterine leiomyoma and ovarian cyst and serum PAEs level.
【作者单位】：上海市第一妇婴保健院妇科;复旦大学公共卫生学院营养与食品卫生学教研室;
【基金】：国家自然科学基金(81172673) 上海市卫生局资助课题(2010257)
【分类号】：R737.3

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