体外受精与自然受孕后母儿围生结局的Meta分析

发布时间：2018-11-22 16:23

【摘要】：目的系统评估体外受精-胚胎移植(IVF-ET)术后母亲围生期并发症和新生儿出生结局。方法计算机检索PubMed、EMbase、Cochrane图书馆、中国知网(CNKI)、万方和中国生物医学文献数据库。收集纳入了IVF和自然妊娠做对比分析的文献,采用RevMan5.3软件进行Meta分析。结果纳入了23篇符合要求的文献,共计1 312 651例,其中IVF有113 044例,自然妊娠1 199 607例。IVF母亲的年龄较自然妊娠大,孕周较自然妊娠小,后代出生体质量较自然妊娠轻(P0.05);IVF母亲发生妊娠期高血压(PIH)、前置胎盘、产后出血以及妊娠期糖尿病(GDM)的概率较自然妊娠者高(P0.05);IVF母亲的多胎及剖宫产率均较自然妊娠者高(P0.05);IVF后代小于胎龄儿(SGA)、低体质量儿、死胎以及早产的发生率较自然妊娠后代高(P0.05)。结论 IVF母亲围生期并发症较自然妊娠者高,新生儿出生结局较自然妊娠后代差。
[Abstract]:Objective to evaluate the perinatal complications and neonatal outcomes after in vitro fertilization-embryo transfer (IVF-ET). Methods PubMed,EMbase,Cochrane library, (CNKI), Wanfang and Chinese biomedical literature database were searched by computer. To collect IVF and natural pregnancy to do comparative analysis of literature, RevMan5.3 software for Meta analysis. Results A total of 1 312,651 cases were included in 23 articles, including 113,044 cases of IVF and 1,199,607 cases of natural pregnancy. The age of IVF mother was older than that of natural pregnancy, and the gestational week was smaller than that of natural pregnancy. The birth weight of offspring was lighter than that of natural pregnancy (P0.05). The probability of (PIH), placenta previa, postpartum hemorrhage and gestational diabetes mellitus (GDM) in IVF mother was higher than that in natural pregnancy group (P0.05). The rate of multiple pregnancy and cesarean section of); IVF mother was higher than that of natural pregnancy group (P0.05). The incidence of (SGA), low body weight, stillbirth and preterm delivery in IVF offspring was higher than that in natural pregnant offspring (P0.05). Conclusion the perinatal complications of IVF mothers are higher than those of natural pregnancy, and the neonatal outcome is worse than that of natural pregnancy.
【作者单位】：第三军医大学西南医院生殖医学中心;西藏自治区拉萨市77627部队医院;
【基金】：2015年默克雪兰诺中国生殖医学研究基金(CREATE基金)资助(WX20115-015)
【分类号】：R714.8

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